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Journal of Adhesion Science and Technology Volume 28, 2014 - Issue 3-4: Bio-Inspired Adhesion
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Articles

Two-photon polymerization/micromolding of microscale barbs for medical applications

R.D. BoehmJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.
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B. ChenJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.
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S.D. GittardJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.
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B.N. ChichkovJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.;Laser Zentrum Hannover e.V., Hollerithalle 8, Hannover, 30419, Germany.
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N.A. Monteiro-RiviereJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.;Department of Clinical Sciences, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, 27695, USA.
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A. NasirDepartment of Dermatology, University of North Carolina, Chapel Hill, NC, 27599, USA.;Wake Research Associates, 3100 Duraleigh Rd Ste 304, Raleigh, NC, 27612, USA.
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R.J. NarayanJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.Correspondence[email protected]
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Pages 387-398 | Received 23 May 2011, Accepted 23 Jan 2012, Published online: 10 Aug 2012
 
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Abstract

Tissue barbs are small-scale structures that may be used for sutureless joining of tissues. In this study, several types of tissue barbs were fabricated using two-photon polymerization/micromolding, including two-pronged tissue barbs, eight-pronged tissue barbs, 10-pronged tissue barbs, and 16-pronged tissue barbs. Tissue barb penetration in porcine tissue was observed using confocal laser scanning microscopy. Constructs containing medical tape and tissue barbs were created by applying tissue barbs in a parallel arrangement to Transpore™ medical tape. These results suggest that two-photon polymerization/micromolding is an indirect rapid prototyping approach that may be used for high-throughput replication of tissue barbs and other microstructured solid wound sealants.

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