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Research Article

Short-term behavioral and histological findings following a single concussive and repeated subconcussive brain injury in a rodent model

ORCID Icon, , &
Received 19 Mar 2023, Accepted 23 Apr 2024, Published online: 05 May 2024
 

ABSTRACT

Primary Objective

It is unclear of the correlation between a mild traumatic brain injury (mTBI) and repeated subconcussive (RSC) impacts with respect to injury biomechanics. Thus, the present study was designed to determine the behavioral and histological differences between a single mTBI impact and RSC impacts with subdivided cumulative kinetic energies of the single mTBI impact.

Research Design

Adult male Sprague-Dawley rats were randomly assigned to a single mTBI impact, RSC impact, sham, or repeated sham groups.

Methods and Procedures

Following a weight drop injury, anxiety-like behavior and general locomotive activity and were assessed using the open field test, while motor coordination was evaluated using a rotarod unit. Neuronal loss, astrogliosis, and microgliosis were assessed using NeuN, GFAP and Iba-1 immunohistochemistry. All assessments were undertaken at 3- and 7-days post impact.

Main Outcomes and Results

No behavioral disturbances were observed in injury groups, however, both injury groups did lead to microgliosis following 3-days post-impact.

Conclusions

No pathophysiological differences were observed between a single mTBI impact and RSC impacts of the same energy input. Even though a cumulative injury threshold for RSC impacts was not determined, a threshold still may exist where no pathodynamic shift occurs.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Supplemental data

Supplemental data for this article can be accessed online at https://doi.org/10.1080/02699052.2024.2349144

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.

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