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Journal of Psychoactive Drugs Volume 39, 2007 - Issue 3
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SHORT COMMUNICATION

Gamma-Hydroxybutyric Acid (GHB) Withdrawal: A Case Report

W. R. Murray Bennett Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine at Harborview Medical Center, Seattle, WA
,
Lawrence G. Wilson Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine at Harborview Medical Center, Seattle, WA
&
Peter P. Roy-Byrne Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine at Harborview Medical Center, Seattle, WA
Pages 293-296 | Published online: 08 Sep 2011
 
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Abstract

GHB is an increasingly popular drug of abuse that can be associated in select cases with growing dependence and a severe withdrawal syndrome. While benzodiazepines are recommended for treatment of the withdrawal syndrome, some cases have been described as benzodiazepine-resistant. The authors describe treatment of such a case, which was unsuccessfully treated initially with benzodiazepines, then successfully treated with adjuvant atypical neuroleptics, and offer a possible neurochemical explanation for why such agents may be theoretically more effective than benzodiazepines in treating GHB withdrawal.

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