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Annals of Human Biology Volume 47, 2020 - Issue 5
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Human Biological Survey

Genetic diversity of X-STR markers in Jat Sikh population of Punjab, India and its comparison with other 39 global populations

Sonia Kakkara Department of Forensic Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
,
Pankaj Shrivastavab DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Sagar, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1647-2390
ORCID Icon,
Vivek Sahajpalc Directorate of Forensics Services, Junga, India
,
Arun Sharmab DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Sagar, India
,
Nisha Devib DNA Fingerprinting Unit, State Forensic Science Laboratory, Department of Home (Police), Sagar, India
,
S. P. Mandala Department of Forensic Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
&
R. K. Kumawatd DNA Division, State Forensic Science Laboratory, Jaipur, IndiaORCID Iconhttps://orcid.org/0000-0002-7794-9615
ORCID Icon show all
Pages 490-497 | Received 05 Nov 2019, Accepted 22 Apr 2020, Published online: 01 Jul 2020
 
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Abstract

Background

The Jat Sikh population is the largest endogamous group of Punjab, a state in north-west India, and has not yet been explored for genetic polymorphism based on X-STR genetic markers. In India, which is the second most populous country in the world, only two population studies based on X-STR markers have been reported so far.

Aim

To explore the genetic diversity of 12 X chromosomal STR genetic markers in the Jat Sikh population of Punjab and expand the X-STR polymorphism database.

Subjects and methods

In this study, a total of 200 Jat Sikh individuals (100 males and 100 females) residing in Punjab were investigated for 12 X-STR markers using the Investigator Argus X-12 QS Kit.

Results

The highest power of discrimination (PD) in females (PDf) and males (PDm) was observed to be 0.965 (DXS10135) and 0.929 (DXS10135 and DXS10148), respectively. DXS10135 was found to be the most polymorphic and discriminating locus among all the studied loci in both males and females with highest values of power of discrimination (PD) and polymorphic information content (PIC) as well.

Conclusion

Overall, the studied markers of the Argus 12 X-STR kit provide high polymorphic information which may prove to be an important tool in resolving issues such as missing person identification, incest, immigration disputes, kinship analysis and genealogical studies. The dataset obtained from this study will add to the present database of X-STRs.

Acknowledgements

The authors are thankful to Director, FSL, Junga to allow us to use the fragment analysis facility in DNA division of Forensic Science Laboratory, Junga, Himachal Pradesh. The authors are thankful to all the laboratory staff of DNA division for helping us during all the laboratory work.

Disclosure statement

The authors declare that they have no conflict of interest in the conduct of the study.

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