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Abstract
Interpenetrating polymer network (IPN) blend microspheres of chitosan (CS) with poly(vinyl alcohol) (PVA) were prepared by a water-in-oil (W/O) emulsification method. These microspheres were cross-linked with glutaraldehyde (GA) as a cross-linking agent and loaded with ibuprofen (IBU), an anti-inflammatory drug. The prepared microspheres were characterized by FT-IR spectroscopy and differential scanning calorimetry (DSC). The effects of the preparation conditions on the release of IBU were investigated for gastrointestinal tract pH values of 1.2, 6.8, and 7.4 at 37°C. IBU release from the microspheres decreased with increasing IBU/polymer ratio and extent of cross-linking and increased with increasing in CS/PVA ratio.
ACKNOWLEDGMENTS
The author is grateful to Atabay Company (Turkey) for the supply of the ibuprofen.
Notes
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