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Original Articles

In-Vitro Evaluation of Ibuprofen-Loaded Microspheres Prepared from Novel Chitosan/Poly(vinyl alcohol) Interpenetrating Polymer Network

Pages 371-378 | Published online: 14 Feb 2014
 

Abstract

Interpenetrating polymer network (IPN) blend microspheres of chitosan (CS) with poly(vinyl alcohol) (PVA) were prepared by a water-in-oil (W/O) emulsification method. These microspheres were cross-linked with glutaraldehyde (GA) as a cross-linking agent and loaded with ibuprofen (IBU), an anti-inflammatory drug. The prepared microspheres were characterized by FT-IR spectroscopy and differential scanning calorimetry (DSC). The effects of the preparation conditions on the release of IBU were investigated for gastrointestinal tract pH values of 1.2, 6.8, and 7.4 at 37°C. IBU release from the microspheres decreased with increasing IBU/polymer ratio and extent of cross-linking and increased with increasing in CS/PVA ratio.

ACKNOWLEDGMENTS

The author is grateful to Atabay Company (Turkey) for the supply of the ibuprofen.

Notes

Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lpte.

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