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Original Articles

In-Vitro Evaluation of Ibuprofen-Loaded Microspheres Prepared from Novel Chitosan/Poly(vinyl alcohol) Interpenetrating Polymer Network

REFERENCES

  • Uhrich , K.E. Polymeric systems for controlled release . Chem. Rev. 1999 , 99 , 3181 – 3198 .
  • Alagusundaram , M. ; Madhu , S.C.C. ; Umashankari , K. ; Attuluri , V.B. ; Lavanya , C. ; Ramkanth , S. Microspheres as a novel drug delivery system—A review . Int. J. ChemTech Res. 2009 , 1 ( 3 ), 526 – 534 .
  • Krishna Rao , K.S.V. ; Naidu , B.V.K. ; Subha , M.C.S. ; Sairam , M. ; Aminabhavi , T.M. Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil . (2006). Carbohydr. Polym. 2006 , 66 , 333 – 344 .
  • Rokhade , A.P. ; Patil , S.A. ; Aminabhavi , T.M. Synthesis and characterization of semi-interpenetrating polymer network microspheres of acrylamide grafted dextran and chitosan for controlled release of acyclovir . Carbonhydr. Polym. 2007 , 67 , 605 – 613 .
  • Ke , G. ; Xu , W. ; Yu , W. Preparation and properties of drug loaded chitosan-sodium alginate complex membrane . Int. J. Polym. Mater. Polym. Biomater. 2010 , 59 , 184 – 191 .
  • Singh , J. ; Dutta , P.K. Preparation, antibacterial and physicochemical behavior of chitosan/ofloxacin complexes . Int. J. Polym. Mater. Polym. Biomater. 2010 , 59 , 793 – 807 .
  • Peng , Z. ; Li , Z. ; Shen , Y. ; Zhang , F. ; Peng , X. Fabrication of gelatin/chitosan microspheres with different morphologies and study on biological properties. Polym. Plast. Technol. Eng. 2012, 51, 739–743.
  • Sahoo , D. ; Sahoo , S. ; Mohanty , P. ; Sasmal , S. ; Nayak , P.L. Chitosan: A new versatile bio-polymer for various applications . Design. Monomers Polym. 2009 , 12 ( 5 ), 377 – 404 .
  • Xiong , L. ; He , Z. Release behavior and cytotoxicity of poly(vinyl alcohol)/chitosan blend microspheres containing 2,4-dihydroxy-5-fluoropyrimidine . Polym. Plast. Technol. Eng. 2012 , 51 , 729 – 733 .
  • Ramesh Babu , V. ; Hosamani , K.M. ; Aminabhavi , T.M. Preparation and in-vitro release of chlorothiazide novel pH-sensitive chitosan-N,N-dimethylacrylamide semi-interpenetrating network microspheres Carbohydr . Polym. 2008 , 71 , 208 – 217 .
  • Kawadkar , J. ; Chauhan , M.K. Intra-articular delivery of genipin cross-linked chitosan microspheres of flurbiprofen: Preparation, characterization, in vitro and in vivo studies Eur . J. Pharm. Biopharm. 2012 , 81 , 563 – 572 .
  • Rokhade , A.P. ; Shelke , N.B. ; Patil , S.A. ; Aminabhavi , T.M. Novel interpenetrating polymer network microspheres of chitosan and methylcellulose for controlled release of theophylline . Carbonhydr. Polym. 2007 , 69 , 678 – 687 .
  • Agnihotri , S.A. ; Aminabhavi , T.M. Novel interpenetraitng network chitosan-poly(ethylene oxide-g-acrylamide) hydrogel microspheres for the controlled release of capecitabine . Int. J. Pharm. 2006 , 324 ( 2 ), 103 – 115 .
  • Sullad , A.G. ; Manjeshwar , L.S. ; Aminabhavi , T.M. Controlled release of theophylline from interpenetrating blend microspheres of poly(vinyl alcohol) and methyl cellulose . J. Appl. Polym. Sci. 2010 , 116 , 1226 – 1235 .
  • Lopes , C.M.A. ; Felisberti , M.I. Mechanical behaviour and biocompatibility of poly(1-vinyl-2-pyrrolidinone)–gelatin IPN hydrogels . Biomaterials 2003 , 24 , 1279 – 1284 .
  • Bhattacharya , S.S. ; Mishra , A. ; Pal , D. ; Ghosh , A.K. ; Ghosh , A. ; Banerjee , S. ; Kumar Sen , K. Synthesis and characterization of poly(acrylic acid)/poly(vinyl alcohol)-xanthan gum interpenetrating network (IPN) superabsorbent polymeric composites . Polym. Plast. Technol. Eng. 2012 , 51 , 878 – 884 .
  • Vasudev , S.C. ; Chandy , T. ; Sharma , C.P. Development of chitosan/polyethylene vinyl acetate co-matrix: controlled release of aspirin-heparin for preventing cardiovascular thrombosis . Biomaterials 1997 , 18 , 375 – 381 .
  • Wang , Q. ; Dong , Z. ; Du , Y. ; Kennedy , J.F. Controlled release of ciprofloxacin hydrochloride from chitosan/polyethylene glycol blend films . Carbohydr. Polym. 2007 , 69 , 336 – 343 .
  • Kim , S.J. ; Park , S.J. ; Kim , S.I. Synthesis and characteristics of interpenetrating polymer network hydrogels composed of poly(vinyl alcohol) and poly(Nisopropylacrylamide) . React. Func. Polym. 2003 , 55 , 61 – 67 .
  • Vidyalakshmi , K. ; Rashmi , K.N. ; Pramod Kumar , T.M. ; Siddaramaiah . Studies on formulation and in vitro evaluation of PVA/chitosan blend films for drug delivery J . Macromol. Sci. Part A Pure. Appl. Chem. 2004 , A41 , 1115 – 1122 .
  • Perumal , D. Microencapsulation of ibuprofen and Eudragit®RS 100 by the emulsion solvent diffusion technique . Int. J. Pharm. 2001 , 218 , 1 – 11 .
  • Zheng , J.P. ; Luan , L. ; Wang , H.Y. ; Xi , L.F. ; Yao , K.D. Study on ibuprofen/montmorillonite intercalation composites as drug release system . Appl. Clay Sci. 2007 , 36 , 297 – 301 .
  • Kachrimanis , K. ; Ktistis , G. ; Malamataris , S. Crystallisation conditions and physicomechanical properties of ibuprofen–Eudragit® S100 spherical crystal agglomerates prepared by the solvent-change technique . Int. J. Pharm. 1998 , 173 , 61 – 74 .
  • Valot , P. ; Babab , M. ; Nedelecc , J.-M. ; Sintes-Zydowicz , N. Effects of process parameters on the properties of biocompatible ibuprofen-loaded microcapsules . Int. J. Pharm. 2009 , 369 , 53 – 63 .
  • Alnaief , M. ; Antonyuk , S. ; Hentzschel , C.M. ; Leopold , C.S. ; Heinrich , S. ; Smirnova , I. A novel process for coating of silica aerogel microspheres for controlled drug release applications . Micropor. Mesopor. Mater. 2012 , 160 , 167 – 173 .
  • Perge , L. ; Robitzer , M. ; Guillemot , C. ; Devoisselle , J.-M. ; Quignard , F.O. ; Legrand , P. New solid lipid microparticles for controlled ibuprofen release: Formulation and characterization study . Int. J. Pharm. 2012 , 422 , 59 – 67 .
  • Sogias , I.A. ; Williams , A.C. ; Khutoryanskiy , V.V. Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen . Int. J. Pharm. 2012 , 436 , 602 – 610 .
  • Ramesh Babu , V. ; Krishna Rao , K.S.V. ; Sairam , M. ; Naidu , B.V.K. ; Hosamani , K.M. ; Aminabhavi , T.M. pH sensitive interpenetrating network microgels of sodium alginate-acrylic acid for the controlled release of ibuprofen. J. Appl . Polym. Sci. 2006 , 99 , 2671 – 2678 .
  • Zhang , L. ; Zhang , G. ; Lu , J. ; Liang , H. Preparation and characterization of carboxymethyl cellulose/polyvinyl alcohol blend film as a potential coating material . Polym. Plast. Technol. Eng. 2013 , 52 , 163 – 167 .
  • Şanlı , O. ; Karaca , İ. ; Işıklan , N. Preparation, characterization, and salicylic acid release behavior of chitosan/poly(vinyl alcohol) blend microspheres . J. Appl. Polym. Sci. 2009 , 111 , 2731 – 2740 .
  • Khoo , C.G.L. ; Frantzich , S. ; Rosinski , A. ; Sjöströmb , M. ; Hoogstraate , J. Oral gingival delivery systems from chitosan blends with hydrophilic polymers . Eur. J. Pharm. Biopharm. 2003 , 55 , 47 – 56 .
  • Maheshwari , M. ; Ketkar , A.R. ; Chauhan , B. ; Patil , V.B. ; Paradkar , A.R. Preparation and characterization of ibuprofen–cetyl alcohol beads by melt solidification technique: effect of variables . Int. J. Pharm. 2003 , 261 , 57 – 67 .
  • Kumbar , S.G. ; Soppimath , K.S. ; Aminabhavi , T.M. Synthesis and characterization of polyacrylamide-grafted chitosan hydrogel microspheres for the controlled release of indomethacin . J. Appl. Polym. Sci. 2003 , 87 , 1525 – 1536 .
  • Peng , Z. ; Li , Z. ; Shen , Y. Influence of chemical cross-linking on properties of gelatin/chitosan microspheres . Polym. Plast. Technol. Eng. 2012 , 51 , 381 – 385 .
  • Şanlı , O. ; Biçer , E. ; Işıklan , N. In vitro release study of diltiazem hydrochloride from poly(vinyl pyrrolidone)/sodium alginate blend microspheres . J. Appl. Polym. Sci. 2008 , 107 , 1973 – 1980 .
  • Soppimath , K.S. ; Aminabhavi , T.M. Water transport and drug release study from cross-linked polyacrylamide grafted guar gum hydrogel microspheres for the controlled release application . Eur. J. Pharm. Biopharm. 2002 , 53 , 87 – 98 .
  • Kumbar , S.G. ; Aminabhavi , T.M. Synthesis and characterization of modified chitosan microspheres: Effect of the grafting ratio on the controlled release of nifedipine through microspheres . J. Appl. Polym. Sci. 2003 , 89 , 2940 – 2949 .
  • Işıklan , N. ; Inal , M. ; Yiğitoğlu , M. Synthesis and characterization of poly(n-vinyl-2-pyrrolidone) grafted sodium alginate hydrogel beads for the controlled release of indomethacin . J. Appl. Polym. Sci. 2008 , 110 , 481 – 493 .
  • Bajpai , A.K. ; Sharma , M. Preparation and characterization of binary grafted polymeric blends of polyvinyl alcohol and gelatin and evaluation of their water uptake potential . J. Macromol. Sci. Pt. A Pure Appl. Chem. 2005 , 42 ( 5 ), 663 – 682 .
  • Peppas , N.A. Analysis of Fickian non Fickian drug release from polymers . Pharm. Acta Helv. 1985 , 60 ( 4 ), 110 – 111 .
  • Ritger , P.L. ; Peppas , N.A. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices . J. Contr. Rel. 1987 , 5 ( 1 ), 37 – 42 .
  • Babu , V.R. ; Sairam , M. ; Hosamani , K.M. ; Aminabhavi , T.M. Preparation of sodium alginate–methylcellulose blend microspheres for controlled release of nifedipine . Carbohydr. Polym. 2007 , 69 ( 2 ), 241 – 250 .
  • Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/lpte.

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