Bulk Synthesis of Monodisperse and Highly Biocompatible Poly(ɛ-caprolactone)-diol by Transesterification Side-Reactions

ABSTRACT

Ring-opening polymerization of ε-caprolactone was performed at 130°C, under partial vacuum in the presence of stannous octoate as the catalyst and 1,4-butanediol as the initiator. After the termination of polymerization by deionized water, a hydroxyl group formed at the end of the polymer chains. Structure of the synthetic poly(ε-caprolactone)-diols (PCL-diol), molecular weight, polydispersity index, and Cell viability were evaluated. Very narrow distribution in the molecular weight obtained for PCL-diols is due to a new method for synthesis. It was shown that by the increase in PCL-diols, the compatibility of human mesenchymal stem cells grew up.

GRAPHICAL ABSTRACT

KEYWORDS:

• Biocompatible
• MTT assay
• polycaprolactone diol
• transesterification

Acknowledgments

Authors thank Amirkabir University of Technology (Tehran Polytechnic) for general university funding and Mrs. Karimi and Mrs. Ghadamali for their support in the sample preparation for GPC and FTIR.

Compliance with ethical standards

This research is Compliance with ethical standards.