Role of NF-κB in the Anti-Inflammatory Effects of Tocotrienols

The authors are supported by the Intramural Research Program of the National Institute on Aging (Baltimore, MD).

Abstract

The NF-κB family of transcription factors regulates genes that are critical for inflammation and immunity. In most cells, NF-κB function is induced upon activation of cells by various stimuli. However, constitutive NF-κB activity is an equally important aspect of NF-κB function that is particularly relevant to chronic inflammation and cancer. Here, we provide a brief overview of NF-κB biology and discuss the role of NF-κB in mediating the anti-inflammatory effects of tocotrienols

The NF-κB family of transcription factors is a central player in the regulation of inflammation and immune responses. Consequently, NF-κB dysregulation has been implicated in diverse human pathologies ranging from autoimmune diseases to cancers. Additionally, there is considerable interest in the contribution of NF-κB–mediated chronic inflammation in aging. Because NF-κB–dependent gene regulation is important in virtually all mammalian cell types, it is critical to keep in mind some basic features of its functions when considering interventional therapeutics.

• NF-κB
• tocotrienols
• inflammation