149
Views
33
CrossRef citations to date
0
Altmetric
Articles

Role of NF-κB in the Anti-Inflammatory Effects of TocotrienolsFootnote

, PhD & , PhD
Pages 334S-339S | Received 24 May 2010, Published online: 14 Jun 2013

REFERENCES

  • KarinMStaudtLM (eds): “NF-{kappa}B.” Cold Spring HarborNY: Cold Spring Harbor Press, 2010.
  • SenRSmaleST: Selectivity of the NF-{kappa}B response. Cold Spring Harb Perspect Biol 2: a000257, 2010.
  • BasakSKimHKearnsJDTergaonkarVO'DeaEWernerSLBenedictCAWareCFGhoshGVermaIMHoffmannA: A fourth IkappaB protein within the NF-kappaB signaling module. Cell 128: 369– 381, 2007.
  • HaydenMSGhoshS: Shared principles in NF-kappaB signaling. Cell 132: 344– 362, 2008.
  • BonizziGKarinM: The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25: 280– 288, 2004.
  • BowieAO'NeillLA: Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59: 13– 23, 2000.
  • GhoshSKarinM: Missing pieces in the NF-kappaB puzzle. Cell 109 Suppl: S81– S96, 2002.
  • KearnsJDBasakSWernerSLHuangCSHoffmannA: IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J Cell Biol 173: 659– 664, 2006.
  • HaoSBaltimoreD: The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat Immunol 10: 281– 288, 2009.
  • DasSNesaretnamKDasDK: Tocotrienols in cardioprotection. Vitam Horm 76: 419– 433, 2007.
  • SuzukiYJTsuchiyaMWassallSRChooYMGovilGKaganVEPackerL: Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry 32: 10692– 10699, 1993.
  • KhannaSPatelVRinkCRoySSenCK: Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radic Biol Med 39: 1310– 1319, 2005.
  • YapSPYuenKHWongJW: Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. J Pharm Pharmacol 53: 67– 71, 2001.
  • SenCKKhannaSRinkCRoyS: Tocotrienols: the emerging face of natural vitamin E. Vitam Horm 76: 203– 261, 2007.
  • RoySLadoBHKhannaSSenCK: Vitamin E sensitive genes in the developing rat fetal brain: a high-density oligonucleotide microarray analysis. FEBS Lett 530: 17– 23, 2002.
  • TheriaultAChaoJTGaporA: Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. Atherosclerosis 160: 21– 30, 2002.
  • VainerGWPikarskyEBen-NeriahY: Contradictory functions of NF-kappaB in liver physiology and cancer. Cancer Lett 267: 182– 188, 2008.
  • Landesman-BollagESongDHRomieu-MourezRSussmanDJCardiffRDSonensheinGESeldinDC: Protein kinase CK2: signaling and tumorigenesis in the mammary gland. Mol Cell Biochem 227: 153– 165, 2001.
  • ShafferALWrightGYangLPowellJNgoVLamyLLamLTDavisREStaudtLM: A library of gene expression signatures to illuminate normal and pathological lymphoid biology. Immunol Rev 210: 67– 85, 2006.
  • LenzGStaudtLM: Aggressive lymphomas. N Engl J Med 362: 1417– 1429, 2010.
  • ShahSJSylvesterPW: Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. Exp Biol Med (Maywood) 230: 235– 241, 2005.
  • YapWNChangPNHanHYLeeDTLingMTWongYCYapYL: Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. Br J Cancer 99: 1832– 1841, 2008.
  • AhnKSSethiGKrishnanKAggarwalBB: Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem 282: 809– 820, 2007.
  • XuWLLiuJRLiuHKQiGYSunXRSunWGChenBQ: Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells. Nutrition 25: 555– 566, 2009.
  • ShirodeABSylvesterPW: Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling. Biomed Pharmacother 64: 327– 332, 2010.
  • WuSJLiuPLNgLT: Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Mol Nutr Food Res 52: 921– 929, 2008.
  • YamMLAbdul HafidSRChengHMNesaretnamK: Tocotrienols suppress proinflammatory markers and cyclooxygenase-2 expression in RAW264.7 macrophages. Lipids 44: 787– 797, 2009.
  • WuSJNgLT: Tocotrienols inhibited growth and induced apoptosis in human HeLa cells through the cell cycle signaling pathway. Integr Cancer Ther 9: 66– 72, 2010.
  • WadaSSatomiYMurakoshiMNoguchiNYoshikawaTNishinoH: Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett 229: 181– 191, 2005.
  • KuhadABishnoiMTiwariVChopraK: Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits. Pharmacol Biochem Behav 92: 251– 259, 2009.
  • KuhadAChopraK: Attenuation of diabetic nephropathy by tocotrienol: involvement of NFkB signaling pathway. Life Sci 84: 296– 301, 2009.
  • FerrucciLCorsiALauretaniFBandinelliSBartaliBTaubDDGuralnikJMLongoDL: The origins of age-related proinflammatory state. Blood 105: 2294– 2299, 2005.
  • AdlerASKawaharaTLSegalEChangHY: Reversal of aging by NFkappaB blockade. Cell Cycle 7: 556– 559, 2008.
  • SalminenAKaarnirantaK: NF-kappaB signaling in the aging process. J Clin Immunol 29: 397– 405, 2009.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.