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Abstract
Objective: Metabolic syndrome (MS) represents a constellation of conditions, which, taken together, increase an individual's risk for the development of type 2 diabetes and cardiovascular disease. Numerous guidelines have been suggested; however, increasing evidence has suggested that universal recommendations are not applicable across different ethnic groups. To date, no specific screening recommendations exist for the Taiwanese population.
Materials and Methods: A total of 8913 Taiwanese (>18 years) were enrolled and evaluated for MS based on the International Diabetes Federation (IDF) criteria established for the Asian population, in an attempt to reevaluate the appropriate guidelines for diagnosing MS in the Taiwanese population.
Results: Among the risk factors assessed, hypertension (24.72%), hyperglycemia (6.86%), and elevated triglycerides (18.50%) were significantly more prevalent among men (p < 0.01). Low high-density lipoprotein was not significantly different between genders. The prevalence of MS was 24.83% (1171/4716) for men and 15.48% (650/4197) for women. When modified cutoff points for waist circumference (WC) were analyzed (≥86.0 cm for men, ≥76.0 cm for women), the prevalence of MS increased to 40.88% (1928/4716) for men and 27.88% (1170/4197) for women. Not unexpectedly, the odds ratio for developing MS increased with an increasing WC, as well as with an increasing number of risk factors for MS.
Conclusions: The suggested IDF guidelines for defining MS in the Asian population, including WC, seem appropriate for use in the Taiwanese population but need modification. Further studies are warranted to identify other anthropometric measures specific to the population that would enhance the ability to diagnose MS.
Fig. 1 Receiver operator characteristic (ROC) curves for waist circumference (WC) to predict the presence of ≥2 risk factors for metabolic syndrome in (A) men and (B) women. The areas under the ROC curves (AUC) were observed through multiple logistic regression analysis by adjusting age, tobacco use, and alcohol use. The estimated AUC was 0.769 (standard error [SE] = 0.008) for men and 0.840 (SE = 0.011) for women, respectively. The best cutoff of WC was observed at 86.0 cm in men and 76.0 cm in women.
![Fig. 1 Receiver operator characteristic (ROC) curves for waist circumference (WC) to predict the presence of ≥2 risk factors for metabolic syndrome in (A) men and (B) women. The areas under the ROC curves (AUC) were observed through multiple logistic regression analysis by adjusting age, tobacco use, and alcohol use. The estimated AUC was 0.769 (standard error [SE] = 0.008) for men and 0.840 (SE = 0.011) for women, respectively. The best cutoff of WC was observed at 86.0 cm in men and 76.0 cm in women.](/cms/asset/d8b0b8ce-dc88-48e3-adc7-002453978299/uacn_a_10719966_f0001.jpg)
Table 1. Demographics of Participants by Sex (N = 8913)1
Table 2. Prevalence of the Metabolic Syndrome Components (Except Waist Circumference) of Participants by Sex (N = 8913)1
Table 3. Prevalence of Waist Circumference of Participants by Sex (N = 8913)
Table 4. Summary of the OR for Various WC by Examining Patients Identified with More Than 1, 2, or 3 of the Potential Risk Factors for MS* (N = 8913)
Notes
The authors declare that they have no competing interests.