Flexible Synthesis of Polyhydroxylated 2,2-Disubstituted Pyrrolidines

Abstract

Many polyhydroxylated pyrrolidines and piperidines have attracted considerable attention because they have been shown to selectively inhibit the oligosaccharide processing enzymes by mimicking the transition state.² Especially their potential to exhibit antibacterial, antiviral³ and cancerostatic activities⁴ has led to a tremendous interest and demand for flexible synthetic strategies.