Flexible Synthesis of Polyhydroxylated 2,2-Disubstituted Pyrrolidines

REFERENCES AND NOTES

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• Significant spectral data for 7: 1H NMR (CDCl3) (two amide rotamers in a ratio of 7:3) δ 5.98 (d, J = 6.1 Hz, CH=CH), 5.93 (d, J = 6.1 Hz, CH=CH), 5.45 (d, J = 6.1 Hz, CH=CH), 5.38 (d, J = 6.1 Hz, CH=CH), 4.49 (d, J = 3.5 Hz, CHOMe), 4.47 (d, J = 3.2 Hz, CHOMe), 3.95 (t, J = 9.2 Hz, C-3 glucose), 3.71 (s, CO2Me) and 3.69 (s, CO2Me). LRMS (EI, 70 eV): m/z 673 (M+). Anal. Calcd for C39H47NO9 (673.80): C, 69.52; H, 7.03; N, 2.08. Found: C, 69.30; H, 7.11; N, 2.04.
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