Concept, Discovery and Development of MMI Linkage: Story of a Novel Linkage: for Antisense Constructs

Abstract

Methylene(methylimino) or MMI linkage is a novel backbone modification that has enormous potential in the oligonucleotide-based antisense therapeutics as a replacement for the natural phosphodiester linkage. This presentation synopsis covers the rationale, detailed SAR on the optimization process of this linkage vs. others, various synthetic strategies to construct MMI linkage and a brief discussion on the biological properties of the modified oligonucleotides.

Notes

The names of these colleagues appear in the references cited in this account and three other MMI related abstracts in this volume