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Abstract
Stress tolerance is a vital attribute for all living beings to cope with environmental adversities. IrrE (also named PprI) from Deinococcus radiodurans enhances resistance to extreme radiation stress by functioning as a global regulator, mediating the transcription of genes involved in deoxyribonucleic acid (DNA) damage response (DDR). The expression of IrrE augmented the resilience of various species to heat, radiation, oxidation, osmotic stresses and inhibitors, encompassing bacterial, fungal, plant, and mammalian cells. Moreover, IrrE was employed in a global regulator engineering strategy to broaden its applications in stress tolerance. The regulatory impacts of heterologously expressed IrrE have been investigated at the molecular and systems level, including the regulation of genes, proteins, modules, or pathways involved in DNA repair, detoxification proteins, protective molecules, native regulators and other aspects. In this review, we discuss the regulatory role and mechanism of IrrE in the antiradiation response of D. radiodurans. Furthermore, the applications and regulatory effects of heterologous expression of IrrE to enhance abiotic stress tolerance are summarized in particular.
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Acknowledgements
The work was financially supported by the National Key Research and Development Program of China (2018YFA0900100) and Tianjin Municipal Science and Technology Bureau (19JCJQJC63300, 21JCZXJC00020).
Author contributions
LW (Li Wang) drafted the manuscript text. LW (Li Wang) and B-Z L (Bing-Zhi Li) contributed to the conception and design of the article. KC (Kai Chen) helped to prepare the figures. Y-S T (Yong-Shui Tan), SN (Samuel Ntakirutimana), Z-H L (Zhi-Hua Liu) and B-Z L (Bing-Zhi Li) revised the manuscript. All authors read and approved the final manuscript.
Disclosure statement
The authors declare that they have no competing interests.