Abstract
The oxovanadium(IV) Schiff base metal complex (ISNPV) have been synthesized as well as characterized by using micro analytical and traditional spectroscopic techniques. The spectral findings were utilized to validate the formation of ISNPV with structure exhibited square pyramidal geometry. The in vitro antibacterial activities of ISNPV were investigated to five different bacterial stains such as S. aureus, S. epidermidis, B. cereus, B. amyloliquefaciens and B. subtilis. The obtained result have suggested that the ISNPV has highest antibacterial activity against S. aureus than the other bacterial stains. The in vitro antioxidant activity like DPPH free radical scavenging assay method was studied by ISNPV in DMSO medium. Because it scavenges all free radicals, the ISNPV possesses higher antioxidant activity than the free ligand. UV-visible absorption and emission spectral techniques were used to investigate the binding of CT-DNA to the ISNPV. Both the spectral data indicate that the ISNPV binds the double helix structure of CT-DNA via an intercalation mode. Additionally, investigate the interactions of ISNPV with the protein molecules like BSA/HAS has been investigated using absorption and emission techniques. The absorption intensity of metal complex increases as well as the emission intensity of protein molecules ability decreases due to the binding nature of ISNPV with BSA/HSA protein molecules. The binding nature of ISNPV with bio molecules such as CT-DNA, BSA and HSA was also validated using molecular docking approach.
Graphical Abstract
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The oxovanadium(IV) Schiff base metal complex (ISNPV) were synthesized and analyzed by various spectral approaches.
The moderate antibacterial activities of ISNPV than free ligand.
The ISNPV has excellent DPPH free radical scavenging activities.
The interactions of ISNPV with CT-DNA, BSA and HSA were evaluated by using UV-visible absorption and emission spectral methods.
The nature of interaction of ISNPV with biomolecules was also validated by molecular docking methods.
Highlights
Communicated by Ramaswamy H. Sarma
Acknowledgement
The authors thank DST-FIST and Management, Principal and staff members of V.O. Chidambaram College, Saveetha School of Engineering, SIMATS, Saveetha University and Pope’s College for their research facilities.
Disclosure statement
No potential conflict of interest was reported by the authors.