Abstract
Children born with severe homozygous protein C deficiency do not survive beyond the neonatal period unless they receive protein C replacement. Protein C concentrate (Baxter Biosciences, Vienna) is usually given intravenously via a central venous catheter. The authors describe 2 children in whom protein C concentrate was successfully administered by subcutaneous infusion after they had had recurrent central line infections. Alternate daily doses of 250–350 IU/kg resulted in trough protein C levels of >25 IU/dL. In the follow-up period of 1–2 years neither child has had a thrombotic episode or purpuric skin lesions, and infusions are managed in the home by their parents.
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