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Pediatric Hematology and Oncology Volume 22, 2005 - Issue 7
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Articles

IDENTIFICATION OF PROGNOSIS MARKERS IN PEDIATRIC HIGH-RISK ACUTE LYMPHOBLASTIC LEUKEMIA

Zakia Al-Lamki Department of Child Health, Hematology/Oncology Unit, College of Medicine, Sultan Qaboos University, Al-KhodOman
, FRCPCH,
Yasser A. Wali Department of Child Health, Hematology/Oncology Unit, College of Medicine, Sultan Qaboos University, Al-KhodOman
, MD, FRCPCH,
Shah M. Wasifuddin Department of Child Health, Hematology/Oncology Unit, College of Medicine, Sultan Qaboos University, Al-KhodOman
, MD,
Mathew Zachariah Department of Child Health, Hematology/Oncology Unit, College of Medicine, Sultan Qaboos University, Al-KhodOman
, MD,
Rayhanah Al-Mjeni Department of Genetics, College of Medicine, Sultan Qaboos University, Al-KhodOman
, MSc,
Changping Li Texas Children's Cancer Center and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
, MD,
Shanmugakonar Muralitharan Department of Clinical Biochemistry, College of Medicine, Sultan Qaboos University, Al-KhodOman
, MSc, MPhil,
Khalsa Al-Kharusi Department of Child Health, Hematology/Oncology Unit, College of Medicine, Sultan Qaboos University, Al-KhodOman
, BSc,
Preethi Gunaratne Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
, PhD,
Leif Peterson Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, USA
, PhD,
Richard Gibbs Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
, PhD,
Marie-Claude Gingras Texas Children's Cancer Center and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
, PhD &
Judith F. Margolin Texas Children's Cancer Center and Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
, MD show all
Pages 629-643 | Received 18 Mar 2005, Accepted 07 Jun 2005, Published online: 09 Jul 2009
 
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Abstract

Gene expression profiling may improve the understanding of the biology behind relapse in pediatric acute lymphoblastic leukemia. Using suppression subtractive hybridization (SSH), cDNA concatenated sequencing (CCS), and reverse transcriptase real-time quantitative polymerase chain reaction (RT-RQ-PCR) on high-risk patient samples with nondeterminant chromosomal translocation, the authors identified 3 genes that were significantly overexpressed in the nonrelapsed patients: the calcium/calmodulin-dependent serine protein kinase (CASK), subunit 2 of the cofactor required for SP1 transcriptional activation (CRSP2), and granzyme K (GZMK). The level of expression of these biomarkers may help identify patients with potentially good prognosis within a group otherwise at high risk of relapse.

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