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Pediatric Hematology and Oncology Volume 22, 2005 - Issue 1
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TOXICITY TO TOPICAL DIMETHYL SULFOXIDE IN A PEDIATRIC PATIENT WITH ANTHRACYCLINE EXTRAVASATION

M. E. Llinares Division of Hematology Oncology, Pediatric Department, University Hospital “Virgen de la Arrixaca,”, MurciaSpain
,
M. Bermúdez Division of Hematology Oncology, Pediatric Department, University Hospital “Virgen de la Arrixaca,”, MurciaSpain
,
J. L. Fuster Division of Hematology Oncology, Pediatric Department, University Hospital “Virgen de la Arrixaca,”, MurciaSpain
,
M. S. Dílaz Division of Hematology Oncology, Pharmacy Department, University Hospital “Virgen de la Arrixaca,”, MurciaSpain
&
C. M. González Division of Hematology Oncology, Pharmacy Department, University Hospital “Virgen de la Arrixaca,”, MurciaSpain
Pages 49-52 | Received 06 Feb 2004, Accepted 01 Oct 2004, Published online: 26 Aug 2009
 
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Abstract

Accidental extravasation of vesicant chemotherapy may cause important tissue injuries. Nowadays, the majority of authors propose topical dimethyl sulfoxide (DMSO), with or without local cooling, as the treatment of choice for anthracyclines extravasation. No significant toxicity has been reported when DMSO is used as topical treatment. In this report, we describe a case of local toxicity consisting of severe pain after its use in a pediatric patient. Illustration shows extravasation area.

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