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Pediatric Hematology and Oncology Volume 24, 2007 - Issue 1
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OVARIAN TISSUE CRYOSTORAGE AND GRAFTING: An Option to Preserve Fertility in Pediatric Patients with Malignancies

Federica Moffa Reproductive Medicine and IVF Unit, Department of Gynaecological and Obstetrical Sciences, University of Turin, OIRM–S., Anna Hospital, Turin, Italy
,
Chiara Perono Biacchiardi Reproductive Medicine and IVF Unit, Department of Gynaecological and Obstetrical Sciences, University of Turin, OIRM–S., Anna Hospital, Turin, Italy
,
Franca Fagioli Department of Pediatrics, University of Turin, OIRM–S., Anna Hospital, Turin, Italy
,
Eleonora Biasin Department of Pediatrics, University of Turin, OIRM–S., Anna Hospital, Turin, Italy
,
Alberto Revelli Reproductive Medicine and IVF Unit, Department of Gynaecological and Obstetrical Sciences, University of Turin, OIRM–S., Anna Hospital, Turin, Italy
,
Marco Massobrio Reproductive Medicine and IVF Unit, Department of Gynaecological and Obstetrical Sciences, University of Turin, OIRM–S., Anna Hospital, Turin, Italy
&
Enrico Madon Department of Pediatrics, University of Turin, OIRM–S., Anna Hospital, Turin, Italy
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Pages 29-44 | Received 20 Jun 2006, Accepted 16 Aug 2006, Published online: 09 Jul 2009
 
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Abstract

Fertility preservation in childhood cancer has become an important area of investigation due to increasing survival rates after cancer therapy. For these patients with an increased risk of infertility and premature ovarian failure, cryopreservation of ovarian tissue is a promising tool to preserve at least part of the reproductive potential. In recent years significant improvements have been achieved in this area, and 2 live births after autografting of frozen–thawed ovarian tissue have been reported. However, further research is needed to assess the clinical effectiveness of ovarian cryopreservation, to optimize the technique, and to limit the risk of reintroducing cancer cells in the patient with the graft.

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