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Pediatric Hematology and Oncology Volume 24, 2007 - Issue 6
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Case Reports

PYRIDOXINE AND PYRIDOSTIGMINE TREATMENT IN VINCRISTINE-INDUCED NEUROPATHY

Hamit Ozyurek Faculty of Medicine, Department of Pediatrics, Section of Neurology, Ondokuz Mayis University, Samsun, Turkey
, MD,
Hande Turker Faculty of Medicine, Department of Neurology, Ondokuz Mayis University, Samsun, Turkey
, MD,
Mehtap Akbalik Faculty of Medicine, Department of Pediatrics, Section of Neurology, Ondokuz Mayis University, Samsun, Turkey
, MD,
Ayse Oytun Bayrak Faculty of Medicine, Department of Neurology, Ondokuz Mayis University, Samsun, Turkey
, MD,
Hulya Ince Faculty of Medicine, Deparment of Pediatrics, Ondokuz Mayis University, Samsun, Turkey
, MD &
Feride Duru Faculty of Medicine, Department of Pediatrics, Section of Neurology, Ondokuz Mayis University, Samsun, Turkey
, MD
Pages 447-452 | Received 13 Jan 2007, Accepted 11 May 2007, Published online: 09 Jul 2009
 
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Abstract

Vincristine is a commonly used antineoplastic drug and frequently causes neurotoxicity. Here the authors report a 4-year-old boy with acute lymphoblastic leukemia in whom vincristine-induced peripheral and cranial neuropathy developed during remission induction therapy. The patient seemed to benefit from pyridoxine and pyridostigmine therapy greatly and this therapy is recommended in patients with severe vincristine-induced neuropathy.

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