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Pediatric Hematology and Oncology Volume 25, 2008 - Issue 2
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Case Reports

METHOTREXATE RECHALLENGE FOLLOWING DELAYED CLEARANCE AND LIFE-THREATENING TOXICITY

Parameswaran Anoop Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK
,
Sucheta J. Vaidya Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK
&
Julie Mycroft Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Surrey, UK
Pages 119-121 | Received 17 Jan 2007, Accepted 31 Oct 2007, Published online: 09 Jul 2009
 
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Abstract

Life-threatening toxicity is often a contraindication for cytotoxic treatment. Many childhood malignancies have good outcomes with appropriate aggressive chemotherapy. It is not easy to decide whether to subject a child with a good prognostic tumor to a drug that has previously caused significant toxicity. One such situation is documented in this report.

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