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Case Reports

TRANSIENT MYELOPROLIFERATIVE DISORDER AND EOSINOPHILIC PERICARDIAL EFFUSION IN A DOWN SYNDROME NEONATE

, DNB, , MD, , MD & , MD, DM
Pages 123-129 | Received 12 Jun 2007, Accepted 14 Dec 2007, Published online: 09 Jul 2009
 

Abstract

Transient myeloproliferative disorder seen in neonates with Down syndrome is often thought to have a benign course. The authors describe the clinical and laboratory profile of a neonate with Down phenotype and transient myeloproliferative disorder with pericardial effusion as co-morbidity. Pericardial fluid analysis showed eosinophils. Pericardial effusion resolved with prednisolone therapy. Regression in hepatosplenomegaly with clearance of blasts was seen by third week of illness. The clinical course suggested a benign infiltration of the pericardium. Presence of eosinophils supports the differentiating capability of the blast cells in transient myeloproliferative disorders.

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