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Pediatric Hematology and Oncology Volume 26, 2009 - Issue 1
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EXPRESSION OF PTEN AND SHP1, INVESTIGATED FROM TISSUE MICROARRAYS IN PEDIATRIC ACUTE LYMPHOBLASTIC, LEUKEMIA

Fredrika Gauffin Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden
, MD, PhD (Cand),
Eva Diffner Center for Molecular Pathology, Malmö University Hospital, Malmö, Sweden
, PhD (Cand),
Bertil Gustafsson Department of Pathology, Faculty of Health Sciences, Linköping University Hospital, Sweden
, MD, PhD,
Ann Nordgren Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
, MD, PhD,
Anette Gjörloff Wingren Department of Tumor Biology, Lund University, Malmö University Hospital, Malmö, Sweden
, PhD,
Birgitta Sander Department of Laboratory Medicine, Div of Pathology, Karolinska Institutet, Stockholm, Sweden
, MD, PhD,
Jenny Liao Persson Department of Laboratory Medicine, Division of Pathology, Lund University, Malmö, Sweden
, PhD &
Britt Gustafsson Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden
, MD, PhD show all
Pages 48-56 | Received 06 Jan 2009, Accepted 11 Jan 2009, Published online: 09 Jul 2009
 
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Abstract

PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.

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