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Pediatric Hematology and Oncology Volume 26, 2009 - Issue 7
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Articles

TESTICULAR FUNCTION AFTER TREATMENT FOR ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) IN PREPUBERTAL AND PUBERTAL BOYS

Maryna Krawczuk-Rybak Department of Pediatric Oncology and Hematology, Medical University, Bialystok, Poland
, MD, PhD,
Elzbieta Solarz Department of Pediatric Oncology and Hematology, Medical University, Bialystok, Poland
, MD, PhD,
Jolanta Wysocka Department of Pediatric Diagnostic Laboratory, Medical University, Bialystok, Poland
, PhD,
Michal Matysiak Department of Pediatrics, Hematology and Oncology, Medical University, Warsaw, Poland
, MD, PhD,
Artur Gadomski Department of Pediatrics, Hematology and Oncology, Medical University, Warsaw, Poland
, MD, PhD,
Bernarda Kazanowska Department of Pediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw, Poland
, MD, PhD &
Dorota Sega-Pondel Department of Pediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw, Poland
, MD show all
Pages 504-514 | Received 21 Mar 2008, Accepted 27 Feb 2009, Published online: 08 Oct 2009
 
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Abstract

Testicular function was evaluated in 59 male (27 prepubertal and 32 pubertal) survivors treated for ALL according to two different protocols. Serum inhibin B, FSH, testosterone, LH, and testicular volume were measured. In both groups the mean values of inhibin B were lower than control, whereas the other analyzed parameters were comparable. The inhibin B-to-FSH ratio was reduced as compared to the control. Testicular volume was lower than in healthy pubertal patients. The results show that treatment for ALL has a negative effect on spermatogenesis, regardless of the age at treatment and type of therapy.

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