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Pediatric Hematology and Oncology Volume 26, 2009 - Issue 5
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Articles

PANEL REACTIVE ANTIBODY IN THALASSEMIC SERUM INHIBITS PROLIFERATION AND DIFFERENTIATION OF CORD BLOOD CD34+ CELLS IN VITRO

Jian-Pei Fang Department of Pediatrics, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
, MD,
Lu-Hong Xu Department of Pediatrics, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
, PhD,
Xing-Ge Yang Department of Pediatrics, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
, MD,
Yan-Feng Wu Department of Pediatrics, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
, BS,
Wen-Jun Weng Department of Pediatrics, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
, MD &
Hong-Gui Xu Department of Pediatrics, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
, MD
Pages 338-344 | Received 29 Jul 2008, Accepted 18 Mar 2009, Published online: 13 Aug 2009
 
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Abstract

Thalassemic children are at a high risk of graft rejection in cord blood transplantation. To investigate this possible mechanism, the authors evaluated the effect of panel reactive antibody on the growth of CD34+ cells in vitro. On semisolid medium, CD34+ cells derived from cord blood were incubated with thalassemic serum, and colony-forming units were counted after 10 days of culture. After incubation with serum-specific panel reactive antibody, profound decreases were found in the numbers of CFU-GM, CFU-GEMM and BFU-E compared with controls. The results indicated that serum-specific panel reactive antibody might have an apparent inhibition effect on proliferation and differentiation of cord blood CD34+ cells.

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