Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis

ABSTRACT

Purpose: To review the clinical manifestations, cerebrospinal fluid findings and outcomes of patients diagnosed with ocular syphilis.

Methods: Retrospective case review of all patients treated with ocular syphilis at Groote Schuur Hospital in Cape Town, South Africa between January 2008 and January 2013.

Results: A total of 77 eyes of 49 patients were included. Panuveitis was the most common presenting sign (48.9%). A lumbar puncture was performed on 37 patients (75.5%) and 64.8% (24/37) of samples had positive treponemal testing (CSF-FTA) while 24.3% (9/37) had positive non-treponemal testing (CSF-VDRL). Elevated CSF lymphocyte cell count was a strong predictor of neurosyphilis (p = 0.06 for CSF-FTA positive samples and p = 0.03 for CSF-VDRL positive samples).

Conclusion: The majority of patients (64.8%) who underwent lumbar puncture had cerebrospinal fluid findings suggestive of neurosyphilis. Elevated CSF lymphocyte cell count and total protein count are highly suggestive of neurosyphilis.

Keywords:

• Lumbar puncture
• ocular syphilis

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In Response To: Lapere S., Mustak H. and Steffen J. “Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis”

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the conduct and writing of the article.

Financial Disclosures

None of the authors have any financial disclosures or conflict of interest to declare