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Abstract
As a new hormone, betatrophin has gained attention as a potential new target to combat insulin resistance (IR) and diabetes. Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder among women of the reproductive age with long term sequelae which include IR and metabolic syndrome. The aim of this study is to evaluate the circulating plasma betatrophin levels in overweight/obese or lean women with or without PCOS and also to elucidate possible correlations with anthropometric and metabolic parameters. Thirty-two patients with PCOS as well as fifty-three control subjects were enrolled after obtaining informed written consent. Clinical and biochemical parameters of all subjects were determined. Plasma adiponectin, GLP-1 and betatrophin levels were measured by ELISA. Plasma betatrophin levels were significantly increased in lean patients with PCOS compared with lean and obese controls. Moreover, in PCOS group, betatrophin levels were significantly negatively correlated with waist hip ratio (WHR), fasting insulin level (FINS) and HOMA-IR, whereas, significantly positively correlated with adiponectin level. Multiple regression analysis showed that HOMA-IR was an independent factor influencing serum betatrophin levels. Further follow-up studies are needed to highlight whether and how increased betatrophin secretion play an important role in IR and carbohydrates metabolism in patients with PCOS.
Chinese abstract
Betatrophin激素作为一个可治疗胰岛素抵抗 (IR) 和糖尿病的潜在新目标已获得关注。多囊卵巢综合征 (PCOS) 是育龄期女性常见的一种长期内分泌和代谢紊乱的疾病, 包括IR和代谢综合征。本研究的目的是评估伴或不伴有PCOS的超重/肥胖和体型消瘦女性体内的血浆betatrophin水平, 并阐明其与人体生长发育参数及代谢参数可能的相关性。签署知情同意书后, 32名PCOS患者以及53名对照组患者入组。测定所有受试者的临床和生化参数。通过ELISA技术检测血浆脂联素、胰高血糖素样肽-1 (GLP-1) 和betatrophin水平。与消瘦对照组和肥胖对照组相比, 消瘦的PCOS组患者的血浆betatrophin水平显著升高。此外, PCOS组的betatrophin水平与腰臀比 (WHR) 、空腹胰岛素水平 (FINS) 和胰岛素抵抗指数 (HOMA-IR) 显著负相关, 与脂联素水平显著正相关。多元回归分析显示HOMA-IR是影响血清betatrophin水平的一个独立因素。尚需进一步的随访研究来证明是否及如何促进betatrophin分泌在PCOS患者的胰岛素抵抗和碳水化合物代谢中发挥重要作用。
Acknowledgements
We are grateful to all the participants in the study. The authors thank Sun Yunyan, Cai Bing and Liu Hongyan for participants’ recruitment and excellent B-type ultrasonographic examination for ovaries.
Declaration of interest
The authors report no conflicts of interest. This work was supported by the Key Projects of Shanghai Municipal Health Bureau Research Fund [201440033], Shanghai Jiao Tong University Research Funding on Medical and Engineering Interdisciplinary Projects [YG2015ZD08, YG2015MS30], Wang Kuancheng Prize Fund for Medicine, Excellent Physician Fund Project of Shanghai General Hospital, Songjiang District Health Bureau of Climbing Medical Program [0702N14003] and Shanghai Shen Kang Hospital Development Center for chronic disease prevention and control project [SHDC12015304].