475
Views
12
CrossRef citations to date
0
Altmetric
Betatrophin and Metabolic Characteristics in PCOS

Association of betatrophin with metabolic characteristics in overweight/obese and lean women with PCOS

, , , , , , , , , & show all
Pages 238-243 | Received 16 Jun 2016, Accepted 10 Oct 2016, Published online: 14 Dec 2016

References

  • El Hayek S, Bitar L, Hamdar LH, et al. Poly cystic ovarian syndrome: an updated overview. Front Physiol 2016;7:124
  • March WA, Moore VM, Willson KJ, et al. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod 2010;25:544–51
  • Landay M, Huang A, Azziz R. Degree of hyperinsulinemia, independent of androgen levels, is an important determinant of the severity of hirsutism in PCOS. Fertil Steril 2009;92:643–7
  • Sirota I, Stein DE, Vega M, Keltz MD. Insulin resistance and beta-cell function calculated by homeostasis model assessment in lean, overweight, and obese women with polycystic ovary syndrome. J Reprod Med 2016;61:3–10
  • Kumar AN, Naidu JN, Satyanarayana U, et al. Metabolic and endocrine characteristics of Indian women with polycystic ovary syndrome. Int J Fertil Steril 2016;10:22–8
  • Barber TM, Dimitriadis GK, Andreou A, Franks S. Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance. Clin Med 2015;15:s72–6
  • Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell 2013;153:747–58
  • Ren G, Kim JY, Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab 2012;303:E334–51
  • Lickert H. Betatrophin fuels β cell proliferation: first step toward regenerative therapy? Cell Metab 2013;18:5–6
  • Tuhan H, Abaci A, Anik A, et al. Circulating betatrophin concentration is negatively correlated with insulin resistance in obese children and adolescents. Diabetes Res Clin Pract 2016;114:37–42
  • Fu Z, Berhane F, Fite A, et al. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Sci Rep 2014;4:5013
  • Chen X, Lu P, He W, et al. Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance. J Clin Endocrinol Metabol 2015;100:E96–100
  • Rong Guo X, Li Wang X, Chen Y, et al. ANGPTL8/betatrophin alleviates insulin resistance via the Akt-GSK3beta or Akt-FoxO1 pathway in HepG2 Cells. Exp Cell Res 2016;345:158–67
  • Calan M, Yilmaz O, Kume T, et al. Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome. Endocrine 2016;53:271–9
  • Erbag G, Eroglu M, Turkon H, et al. Relationship between betatrophin levels and metabolic parameters in patients with polycystic ovary syndrome. Cell Mol Biol (Noisy-Le-Grand, France) 2016;62:20–4
  • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19–25
  • Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organization technical report series. 2000;894:i–xii, 1–253
  • Chen J, Chen S, Huang P, et al. In vivo targeted delivery of ANGPTL8 gene for beta cell regeneration in rats. Diabetologia 2015;58:1036–44
  • Gusarova V, Alexa CA, Na E, et al. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell 2014;159:691–6
  • Guo K, Lu J, Yu H, et al. Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals. Obesity 2015;23:793–7
  • Barja-Fernandez S, Folgueira C, Seoane LM, et al. Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women. J Clin Endocrinol Metabol 2015;100:E1188–96
  • Abu-Farha M, Abubaker J, Al-Khairi I, et al. Higher plasma betatrophin/ANGPTL8 level in type 2 diabetes subjects does not correlate with blood glucose or insulin resistance. Sci Rep 2015;5:10949
  • Fu Z, Abou-Samra AB, Zhang R. An explanation for recent discrepancies in levels of human circulating betatrophin. Diabetologia 2014;57:2232–4
  • Chen CI, Hsu MI, Lin SH, et al. Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome. Gynecol Endocrinol 2015;31:264–8
  • Aydin K, Arusoglu G, Koksal G, et al. Fasting and post-prandial glucagon like peptide 1 and oral contraception in polycystic ovary syndrome. Clin Endocrinol (Oxf) 2014;81:588–92
  • Lin T, Li S, Xu H, et al. Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study. Hum Reprod 2015;30:2639–44
  • Ko JK, Li HW, Lam KS, et al. Serum adiponectin is independently associated with the metabolic syndrome in Hong Kong, Chinese women with polycystic ovary syndrome. Gynecol Endocrinol 2016;32:390–4
  • Wang Y, Quagliarini F, Gusarova V, et al. Mice lacking ANGPTL8 (betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci USA 2013;110:16109–14
  • Gomez-Ambrosi J, Pascual E, Catalan V, et al. Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes. J Clin Endocrinol Metabol 2014;99:E2004–9

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.