Development of endometrioma after cervical conization

Abstract

The association between cervical conization and subsequent development of endometriosis is uncertain. The objective of this study was to estimate the incidence rate of ovarian endometrioma after cervical conization and to determine factors associated with the development of endometrioma. One hundred forty-two patients who underwent cervical conization at the University of Tokyo Hospital between January 2006 and December 2013 were included in the study. Their medical records were retrospectively studied until April 2015. The incidence rate of postconization endometrioma was calculated. Patients’ characteristics (age, parity, preoperative and postoperative diagnosis and observation period) were analyzed. Six patients developed endometrioma after the cervical conization, and the incidence rate of endometrioma among patients who underwent cervical conization was 10.8 per 1000 person-year (95%CI 3.6–20.5). Patients’ age, percent of nulliparous, postoperative diagnosis and observation period were not associated with the development of postconization endometrioma. A preoperative diagnosis with invasive cancer (p < 0.05) was significantly associated with the development of postconization endometrioma. The incidence rate of endometrioma among patients who underwent cervical conization in the current study was higher than that reported population.

Chinese abstract

宫颈锥切术与子宫内膜异位症随后发展之间的相关性尚不明确。本研究的目的是评估宫颈锥切术后卵巢子宫内膜异位症的发生率并确定与子宫腺肌症发展的相关因素。本研究纳入了2006年1月至2013年12月在东京大学医院接受宫颈锥切治疗的142名患者, 并对她们的病历进行回顾性研究至2015年4月, 计算锥切后子宫腺肌症的发病率, 分析患者基本特征（年龄、孕产情况、术前术后及观察期的诊断）。宫颈锥切后, 6例患者发生子宫腺肌症, 发生率为10.8/1000人年（95%CI 3.6〜20.5）。患者年龄、未生产率、术后及观察期诊断与锥切术后腺肌症的发展无关。术前诊断为浸润癌（p < 0.05）与子宫腺肌症的发生显著相关。目前研究显示宫颈锥切术后患者子宫内膜异位症发生率高于报道人群。

Keywords:

• Cervical intraepithelial neoplasia
• cervical cancer
• cervical conization
• endometriosis
• endometrioma

Acknowledgements

The authors thank medical colleagues in the University of Tokyo Hospital for collecting clinical data.

Disclosure statement

The authors declare that they have no competing interests.

Additional information

Funding

This work was supported by grants from the Ministry of Health, Labor and Welfare, the Ministry of Education (KK).