Relationship between serum anti-Mullerian hormone with vitamin D and metabolic syndrome risk factors in late reproductive-age women

Abstract

The relationship between serum anti-Mullerian hormone (AMH) with vitamin D (25OH-D) and metabolic syndrome (MetS) risk was evaluated in healthy, late reproductive-age (35–49 years) women with regular menstrual cycles. Among the 291 participants (mean age = 42.5 years), most (76.6%, n = 223) were serum vitamin D insufficient (<20 ng/ml). Mean serum levels of AMH and vitamin D were 2.04 ng/mL and 15.9 ng/mL, respectively. There was no correlation between AMH and 25OH-D after adjustment for age (r = −0.093, p = 0.113). Subjects with higher MetS score, higher waist circumference, and higher diastolic blood pressure had significantly higher serum AMH levels when adjusted for age, but the association attenuated when BMI was included. There was no significant correlation between MetS risk components with serum level of AMH or vitamin D. In conclusion, there was no association between AMH with serum 25OH-D or MetS risk factors in this population.

Chinese abstract

在正常月经周期的健康、晚期生育年龄（35-49岁）妇女中评估血清抗缪勒氏激素（AMH）与维生素D（25OH-D）和代谢综合征（MetS）风险之间的关系。在291名受试者中, 平均年龄为42.5岁, 大多数（76.6%, n = 223）血清维生素D不足（<20 ng/ml）。平均血清AMH和维生素D水平分别为2.04 ng/mL和15.9 ng/mL。调整年龄后, AMH与25OH-D之间没有相关性（r = -0.093, p = 0.113）。随着年龄的调整, MetS评分较高、腰围较宽及舒张压较高的受试者的血清AMH水平显著较高, 但BMI被纳入时, 该相关性减弱。MetS风险成分与血清AMH或维生素D水平之间无显著相关性。综上所述, 在此人群中AMH与血清25OH-D或MetS危险因素之间没有相关性。

Keywords:

• Anti-Mullerian hormone
• vitamin D
• metabolic syndrome
• late reproductive-age
• women

Disclosure statement

The authors report no conflicts of interest.