Abstract
Adiponectin and resistin are adipose tissue-derived proteins with antagonistic actions; adiponectin has insulin sensitive properties while resistin is involved in the development of insulin resistance. We analyzed adiponectin and resistin levels in gestational diabetes mellitus (GDM) women to evaluate the association of these adipokines in a very high diabetes prevalence population. An age-matched case-control study of GDM and normal pregnant women in Saudi population. We recruited 90 pregnant women at 24–32 weeks of gestation. Glucose levels (fasting, 1, 2, and 3 h) and lipid parameters (cholesterol, triglyceride, HDL cholesterol, LDL cholesterol) were measured. Serum adiponectin and resistin levels were analyzed using Randox evidence biochip analyzer. Pearson’s correlation coefficient was used to determine the association of adiponectin and resistin with GDM risk factors. GDM women showed significantly low adiponectin and high resistin levels when compared with control group. Pearson’s correlation analysis of adiponectin and resistin in all the subjects with various GDM risk factors showed a negative association of adiponectin (r = −0.32, p = .05) and a positive correlation of resistin (r = 0.41, p = .01) with LDL cholesterol. This study analyzes adiponectin and resistin levels together, as accumulating evidences shows that these are involved in the pathophysiology of GDM. This is going to help to determine in conjunction with traditional risk factors the incremental value of circulating adiponectin and resistin in developing GDM.
Chinese abstract
脂联素和抵抗素是具有拮抗作用的脂肪组织来源的蛋白质;脂联素具有胰岛素敏感特性, 而抵抗素参与胰岛素抵抗的发展。我们分析了妊娠期糖尿病(GDM)妇女的脂联素和抵抗素水平, 以评估这些脂肪因子在非常高的糖尿病患病率人群中的关联性。沙特阿拉伯的GDM和正常孕妇的年龄匹配的病例对照研究。我们招募了90名妊娠24-32周的孕妇。测量葡萄糖水平(空腹, 1小时, 2小时和3小时)和脂质参数(胆固醇, 甘油三酯, 高密度脂蛋白胆固醇, 低密度脂蛋白胆固醇)。使用Randox证据生物芯片分析仪分析血清脂联素和抵抗素水平。 Pearson相关系数用于确定脂联素和抵抗素与GDM危险因素的关联。与对照组相比, GDM女性的脂联素水平显著降低, 抵抗素水平显现增高。 Pearson相关性分析对所有GDM风险因素包括脂联素和抵抗素的相关分析显示, 脂联素负相关(r = -0.32, p = .05), 抵抗素(r = 0.41, p = .01)及低密度脂蛋白胆固醇正相关。这项研究一起分析脂联素和抵抗素水平, 因为越来越多的证据表明这些涉及GDM的病理生理学。这将有助于确定与传统危险因素一起在发展中的GDM中循环脂联素和抵抗素的增量值。
Acknowledgements
The authors would like to express their gratitude to the members of University Diabetes Center and Biochemistry Department at Strategic Center for Diabetes Research, King Saud University, for their support.
Disclosure statement
The authors report no conflicts of interest.