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ABSTRACT
In an ongoing Mediterranean cohort, we compared age-related conditions between 208 HIV-infected persons and 104 matched controls. ≥3 comorbidities were found in 31.0% of HIV-infected patients and 8.7% of controls. Conditions significantly more frequent among the HIV-infected population were: lipid abnormalities, cancer, osteopenia/osteoporosis, liver disease, sexual dysfunction, hearing deficit, sleep disorders, falls, cognitive complaints, being single, living alone, and being elderly at risk. HIV-infected patients aged >70 years had a significantly higher number of cardiovascular risk factors (CVRF) and comorbidities than controls. HIV-infected persons who had never smoked had a higher prevalence of CVRFs, ≥3 comorbidities, liver disease, cancer, and cognitive complaints compared to controls. Factors associated with frailty were being a man who has sex with men, ≥3 CVRFs, nadir CD470 years. The multidisciplinary assessment also revealed concerning findings in social, cognitive, and functional variables among HIV-infected individuals, with a higher prevalence of elderly at risk than among controls.
Acknowledgements
Eugenia Negredo, Cora Loste, Jordi Puig, Marc Matarrodona, Ana Martínez, Patricia Echeverría, Carmina R. Fumaz, Jose A. Muñoz-Moreno, Begoña Lemos, Fauri Tamayo, Margarita Saiz, Carla Estany, Anna Bonjoch, Nerea Blanco and Bonaventura Clotet attended the patients and compiled data on patients and controls. Pau Satorra performed the statistical analysis. Eugenia Negredo and Cora Loste wrote the main manuscript text and prepared the figures. All of the authors reviewed the manuscript.
Disclosure statement
No potential conflict of interest was reported by the author(s).
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