Accentuated aging associated with HIV in a Mediterranean setting occurs mainly in persons aged>70 years: a comparative cohort study (Over50 cohort)

References

• Blanco, J. R., Jarrín, I., Vallejo, M., Berenguer, J., Solera, C., Rubio, R., Pulido, F., Asensi, V., del Amo, J., Moreno, S., & CoRIS (2012). Definition of advanced age in HIV infection: Looking for an age cut-off. AIDS Research and Human Retroviruses, 28(9), 1000–1006. https://doi.org/https://doi.org/10.1089/AID.2011.0377
   PubMed Web of Science ®Google Scholar
• Brennan-Ing, M., Seidel, L., & Karpiak, S. E. (2017). Social support systems and social network characteristics of older adults with HIV. Interdisciplinary Topics in Gerontology and Geriatrics, 42, 159–172. https://doi.org/https://doi.org/10.1159/000448561
   PubMedGoogle Scholar
• Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987). A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. Journal of Chronic Diseases, 40(5), 373–383. https://doi.org/https://doi.org/10.1016/0021-9681(87)90171-8
   PubMedGoogle Scholar
• Edelman, E. J., Gordon, K. S., Glover, J., McNicholl, I. R., Fiellin, D. A., & Justice, A. C. (2013). The next therapeutic challenge in HIV: Polypharmacy. Drugs & Aging, 30(8), 613–628. https://doi.org/https://doi.org/10.1007/s40266-013-0093-9
   PubMed Web of Science ®Google Scholar
• Erlandson, K. M., & Karris, M. Y. (2019). HIV and aging: Reconsidering the approach to management of comorbidities. Infectious Disease Clinics of North America, 33(3), 769–786. https://doi.org/https://doi.org/10.1016/j.idc.2019.04.005
   PubMed Web of Science ®Google Scholar
• Franceschi, C., & Campisi, J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 69(Suppl 1), S4–S9. https://doi.org/https://doi.org/10.1093/gerona/glu057
   PubMed Web of Science ®Google Scholar
• Greene, M., Covinsky, K. E., Valcour, V., Miao, Y., Madamba, J., Lampiris, H., Cenzer, I. S., Martin, J., & Deeks, S. G. (2015). Geriatric syndromes in older HIV-infected adults. JAIDS Journal of Acquired Immune Deficiency Syndromes, 69(2), 161–167. https://doi.org/https://doi.org/10.1097/QAI.0000000000000556
   PubMed Web of Science ®Google Scholar
• Guaraldi, G., Malagoli, A., Calcagno, A., Mussi, C., Celesia, B. M., Carli, F., Piconi, S., De Socio, G. V., Cattelan, A. M., Orofino, G., Riva, A., Focà, E., Nozza, S., & Di Perri, G. (2018). The increasing burden and complexity of multi-morbidity and polypharmacy in geriatric HIV patients: A cross sectional study of people aged 65–74 years and more than 75 years. BMC Geriatrics, 18(1), 99. https://doi.org/https://doi.org/10.1186/s12877-018-0789-0
   PubMed Web of Science ®Google Scholar
• Guaraldi, G., Milic, J., & Mussini, C. (2019). Aging with HIV. Current HIV/AIDS Reports, 16(6), 475–481. https://doi.org/https://doi.org/10.1007/s11904-019-00464-3
   PubMedGoogle Scholar
• Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., Berti, A., Rossi, E., Roverato, A., & Palella, F. (2011). Premature age-related comorbidities among HIV-infected persons compared with the general population. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 53(11), 1120–1126. https://doi.org/https://doi.org/10.1093/cid/cir627
   PubMed Web of Science ®Google Scholar
• Hasse, B., Ledergerber, B., Furrer, H., Battegay, M., Hirschel, B., Cavassini, M., Bertisch, B., Bernasconi, E., Weber, R., & Swiss HIV cohort Study. (2011). Morbidity and aging in HIV-infected persons: The Swiss HIV cohort study. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 53(11), 1130–1139. https://doi.org/https://doi.org/10.1093/cid/cir626
   PubMed Web of Science ®Google Scholar
• Hovstadius, B., & Petersson, G. (2012). Factors leading to excessive polypharmacy. Clinics in Geriatric Medicine, 28(2), 159–172. https://doi.org/https://doi.org/10.1016/j.cger.2012.01.001
   PubMed Web of Science ®Google Scholar
• John, M. D., Greene, M., Hessol, N. A., Zepf, R., Parrott, A. H., Foreman, C., Bourgeois, J., Gandhi, M., & Hare, C. B. (2016). Geriatric assessments and association with VACS index among HIV-infected older adults in San Francisco. JAIDS Journal of Acquired Immune Deficiency Syndromes, 72(5), 534–541. https://doi.org/https://doi.org/10.1097/QAI.0000000000001009
   PubMed Web of Science ®Google Scholar
• Loste, C., Moltó, J., Pérez-Álvarez, N., Puig, J., Echeverría, P., Bonjoch, A., Fumaz, C. R., Lemos, B., Estany, C., Clotet, B., & Negredo, E. (2021). Potential prescribing issues among older HIV-infected subjects in a Mediterranean cohort: Does the current prevalence give cause for concern? British Journal of Clinical Pharmacology, 87(3), 1310–1317. https://doi.org/https://doi.org/10.1111/bcp.14513
   PubMedGoogle Scholar
• Moir, S., & Fauci, A. S. (2009). B cells in HIV infection and disease. Nature Reviews Immunology, 9(4), 235–245. https://doi.org/https://doi.org/10.1038/nri2524
   PubMed Web of Science ®Google Scholar
• Nasi, M., De Biasi, S., Gibellini, L., Bianchini, E., Pecorini, S., Bacca, V., Guaraldi, G., Mussini, C., Pinti, M., & Cossarizza, A. (2017). Ageing and inflammation in patients with HIV infection. Clinical and Experimental Immunology, 187(1), 44–52. https://doi.org/https://doi.org/10.1111/cei.12814
   PubMed Web of Science ®Google Scholar
• Negredo, E., Massanella, M., Puig, J., Pérez-Alvarez, N., Gallego-Escuredo, J. M., Villarroya, J., Villarroya, F., Moltó, J., Santos, J. R., Clotet, B., & Blanco, J. (2010). Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: Clinical implications. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 50(9), 1300–1308. https://doi.org/https://doi.org/10.1086/651689
   PubMed Web of Science ®Google Scholar
• Pathai, S., Bajillan, H., Landay, A. L., & High, K. P. (2014). Is HIV a model of accelerated or accentuated aging? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(7), 833–842. https://doi.org/https://doi.org/10.1093/gerona/glt168
   PubMed Web of Science ®Google Scholar
• Piggott, D. A., Muzaale, A. D., Mehta, S. H., Brown, T. T., Patel, K. V., Leng, S. X., Kirk, G. D., & Landay, A. (2013). Frailty, HIV infection, and mortality in an aging cohort of injection drug users. PloS One, 8(1), e54910. https://doi.org/https://doi.org/10.1371/journal.pone.0054910
   PubMed Web of Science ®Google Scholar
• Schouten, J., Wit, F. W., Stolte, I. G., Kootstra, N. A., van der Valk, M., Geerlings, S. E., Prins, M., Reiss, P., & AGEhIV Cohort Study Group. (2014). Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: The AGEhIV cohort study. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 59(12), 1787–1797. https://doi.org/https://doi.org/10.1093/cid/ciu701
   PubMed Web of Science ®Google Scholar
• Shah, B. M., & Hajjar, E. R. (2021). Polypharmacy, adverse drug reactions, and geriatric syndromes. Clinics in Geriatric Medicine, 28(2), 173–186. https://doi.org/https://doi.org/10.1016/j.cger.2012.01.002
   Google Scholar
• Simioni, S., Cavassini, M., Annoni, J. M., Abraham, Rimbault, Bourquin, A., Schiffer, I., Calmy, V., Chave, A., Giacobini, J. P., Hirschel, E. (2010). Du Pasquier RA. Cognitive dysfunction in HIV patients despite long-standing suppression of viremia. AIDS, 24(9), 1243–1250.
   PubMed Web of Science ®Google Scholar
• Smit, M., Brinkman, K., Geerlings, S., Smit, C., Thyagarajan, K., Sighem, A. v., de Wolf, F., Hallett, T. B., & ATHENA observational cohort. (2015). Future challenges for clinical care of an ageing population infected with HIV: A modelling study. The Lancet Infectious Diseases, 15(7), 810–818. https://doi.org/https://doi.org/10.1016/S1473-3099(15)00056-0
   PubMed Web of Science ®Google Scholar
• Ware, D., Palella, F. J., Jr., Chew, K. W., Friedman, M. R., D'Souza, G., Ho, K., Plankey, M., & Okulicz, J. F. (2018). Prevalence and trends of polypharmacy among HIV-positive and -negative men in the multicenter AIDS cohort study from 2004 to 2016. PloS one, 13(9), e0203890. https://doi.org/https://doi.org/10.1371/journal.pone.0203890
   PubMed Web of Science ®Google Scholar
• Wing, E. J. (2016). HIV and aging. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases, 53, 61–68. https://doi.org/https://doi.org/10.1016/j.ijid.2016.10.004
   PubMed Web of Science ®Google Scholar
• Wyatt, C. M., Winston, J. A., Malvestutto, C. D., Fishbein, D. A., Barash, I., Cohen, A. J., Klotman, M. E., & Klotman, P. E. (2007). Chronic kidney disease in HIV infection: An urban epidemic. AIDS (London, England), 21(15), 2101–2103. https://doi.org/https://doi.org/10.1097/QAD.0b013e3282ef1bb4
   PubMed Web of Science ®Google Scholar