Abstract
Purpose
Dosimetry of Auger electron-emitting nuclear medicine radioisotopes on cellular and DNA scales is essential in order to assess the biological effects and damage of these radioisotopes to the DNA molecule. This study examined the effects of widely used radioisotopes in nuclear medicine and also two therapeutic radioisotopes in the scale of micrometer and nanometer.
Methods
In this paper, on cell scale (micrometer scale), the S-values for widely used Auger electron-emitting diagnostic radioisotopes 123I, 125I, 99mTc, 67Ga, 201Tl and 111In and two therapeutic radioisotopes of 131I and 211At in three different geometrical cell models (spherical, elliptical and cubic) were calculated using Geant4-DNA and the results were compared with the results of other simulation codes as well as the MIRD technique. On DNA scale (nanometer scale), the average number of DNA strand breaks (SSB and DSB) resulting from the direct and indirect effects was calculated for the specified radioisotope.
Results
The results showed that in the cell scale, S-values of the diagnostic radioisotopes were mostly greater than the S-values of the therapeutic radioisotope 131I, but they were less those of 211At. On DNA scale, two different geometric models of DNA molecule were simulated and the results of these two models were compared with each other, as well as with the literature. The results showed that the geometric shape of sugar-phosphate groups has a significant effect on the break rates of DNA molecules.
Conclusions
Among the widely used diagnostic radioisotopes, 201Tl and 125I had the greatest effect on the rate of SSBs and DSBs, respectively, while the 131I therapeutic radioisotope almost had no effect and therapeutic radioisotope of 211At had a moderate effect on the number of breaks.
Disclosure statement
The authors report no conflict of interest.
Additional information
Notes on contributors
Seifi Moradi Mahdi
Seifi Moradi Mahdi, MSc, is a Doctoral Research Student within the Faculty of Physics, at the University of Isfahan, Isfahan, Iran.
Shirani Bidabadi Babak
Shirani Bidabadi Babak, PhD, is an Assistant Professor of Medical Radiation Engineering in the Faculty of Physics at the University of Isfahan, Isfahan, Iran.