Personalised treatment for cognitive dysfunction in individuals with schizophrenia spectrum disorders

ABSTRACT

Cognitive deficits are a well-recognised issue for individuals diagnosed with schizophrenia spectrum disorders. Despite positive group findings for the use of cognitive remediation (CR) interventions, there are substantial individual differences in response to treatment. In addition, the aggregate CR literature reports low moderate effect sizes for cognitive and functional outcomes. Based on personalised medicine theory, this paper uses extant CR literature to examine the individual characteristics determined to predict treatment response. These characteristics, which fall into the broad categories of cognitive, psychological, and biological can be used as tailoring variables to personalise CR to an individual’s unique profile. Personalisation through the use of these tailoring variables has the potential to improve the delivery of CR to maximise treatment outcomes.

KEYWORDS:

• Cognitive remediation
• neurocognition
• personalised treatment
• schizophrenia

Additional information

Funding

This work was supported by [5R34MH100317-02] from the National Intitute of Mental Health and a grant from the Pibly Foundation.