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Abstract
The essential oils (EOs) obtained from Peperomia tetraphylla (PT), P. pereskiifolia (PP), and P. glabella (PG), were evaluated in MAO-A and -B in vitro inhibitory assays. The oils demonstrated IC50 values for MAO-A of 17.4, 71.0, and 21.9 μg/mL for PG, PT and PP, respectively. For MAO-B, just slight inhibitions were observed at 100 μg/mL. By GC-MS analysis, α-copaene (32.6 % PG), (Z)- and (E)-caryophyllene (11.7 % and 10.7 % PP, respectively), viridiflorene (15.1 % PP), benzyl benzoate (43.9 % PT) and benzyl salicylate (16.7 % PT) were identified as mains components. A phenylpropanoid, named methyl chavicol (7.8 %) was also detected for PG, which was reported for the first time for Peperomia species. To the best of our knowledge, this is the first time that the essential oil chemical constitutions and pharmacological potential of these plants are reported.