Extraction of patient-specific boundary conditions from 4D-DSA and their influence on CFD simulations of cerebral aneurysms

Abstract

We developed a new technique for extracting patient-specific inflow conditions, such as the pulse cycle duration and blood flow velocity, from four-dimensional digital subtraction angiography images and experimentally examined its validity. The maximum error between the values extracted by the technique and measured values was 14.3%. We performed blood flow simulations and calculated representative haemodynamic parameters. The maximum differences between the parameters obtained using general and patient-specific inflow conditions were approximately 400%, 150%, and 50% for the velocity, normalised wall shear stress, and pressure loss coefficient, respectively. These results indicate that patient-specific conditions are critical for accurately reproducing aneurysmal haemodynamics.

Keywords:

• Blood flow simulation
• haemodynamics
• cerebral aneurysm
• inflow condition
• 4D-DSA

Acknowledgement

This work was supported by the JSPS KAKENHI under Grant JP20J30001 and approved by the Ethics Committee of the Jikei University School of Medicine.

Disclosure statement

T.S. and K.O. are full-time employees of Siemens Healthcare K.K.