Current Advancement in the Oxadiazole-Based Scaffolds as Anticancer Agents

Abstract

Heterocyclic nucleus is vital in medicinal chemistry and has allured significant attention in chemotherapeutic domain. Oxadiazole, a five-membered nitrogen–oxygen-containing heterocyclic core has remarkable anticancer activity. Mechanism associated in defeating tumor corresponds with inhibiting various enzymes and growth factors. Considering the importance of oxadiazole and its derivatives in this panic issue worldwide, this review has discussed research carried out from last 7 years and also their future outlook in drug development as antineoplastic agents. The objective of this review is to emphasize on anticancer activity of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives. The precised features and framework of each research topic is introduced for helping the readers in understanding the perspective of the context in better way.

Keywords:

• Anticancer
• apoptosis
• cytotoxic agents
• heterocycles
• oxadiazole

Acknowledgements

Garima Kapoor, Parul Grover, Kandasamy Nagarajan and Shadab Ahmad are deeply indebted to the Director Dr. (Col.) A. Garg and Joint Director, Dr. Manoj Goel, KIET Group of Institutions for their inspiration and support. We also express gratitude to Dr. Jagannath Sahoo, Principal, KIET School of Pharmacy, for his motivation and guidance.

Disclosure statement

The authors declare no conflicts of interest.