Current Advancement in the Oxadiazole-Based Scaffolds as Anticancer Agents

References

• K. Nepali, S. Sharma, M. Sharma, P. M. Bedi, and K. L. Dhar, “Rational Approaches, Design Strategies, Structure Activity Relationship and Mechanistic Insights for Anticancer Hybrids,” European Journal of Medicinal Chemistry 77 (2014): 422–87.
   PubMed Web of Science ®Google Scholar
• K. Ahmed, S. Prabhakar, M. J. Ramaiah, P. V. Reddy, C. R. Reddy, A. Mallareddy, N. Shankaraiah, T. L. N. Reddy, S. N. C. V. L. Pushpavalli, and M. Pal-Bhadra, “Synthesis and Anticancer Activity of Chalcone-Pyrrolobenzodiazepine Conjugates Linked via 1,2,3-Triazole Ring Side-Armed with Alkane Spacers,” European Journal of Medicinal Chemistry 46 (2011): 3820–31.
   PubMed Web of Science ®Google Scholar
• Cancer Facts and Figures. American Cancer Society (2018).
   Google Scholar
• F. Bray and B. Moller, “Predicting the Future Burden of Cancer,” Nature Reviews Cancer 6, no. 1 (2006): 63–74.
   PubMed Web of Science ®Google Scholar
• K. Lal and P. Yadav, “Recent Advancements in 1,4-Disubstituted 1H-1,2,3-Triazoles as Potential Anticancer Agents,” Anti-Cancer Agents in Medicinal Chemistry 18, no. 1 (2018): 21–37.
   PubMed Web of Science ®Google Scholar
• A. Sethiya, D. K. Agarwal, and S. Agarwal, “Current Trends in Drug Delivery System of Curcumin and Its Therapeutic Applications,” Mini Reviews in Medicinal Chemistry 20, no. 13 (2020): 1190–232.
   PubMed Web of Science ®Google Scholar
• I. A. Cree, L. Knight, F. Di Nicolantonio, S. Sharma, and T. Gulliford, “Chemosensitization of Solid Tumors by Modulation of Resistance Mechanisms,” Current Opinion in Investigational Drugs (London, England : 2000) 3, no. 4 (2002): 634–40.
   PubMedGoogle Scholar
• J. Soni, A. Sethiya, N. Sahiba, D. K. Agarwal, and S. Agarwal, “Contemporary Progress in the Synthetic Strategies of Imidazole and Its Biological Activities,” Current Organic Synthesis 16, no. 8 (2019): 1078–104.
   PubMed Web of Science ®Google Scholar
• Y. Wang, D. R. Sauer, and S. W. Djuric, “A Simple and Efficient One Step Synthesis of 1,3,4-Oxadiazoles Utilizing Polymer-Supported Reagents and Microwave Heating,” Tetrahedron Letters. 47, no. 1 (2006): 105–8.
   Web of Science ®Google Scholar
• R. M. Shingare, Y. S. Patil, J. N. Sangshetti, R. B. Patil, D. P. Rajani, and B. R. Madje, “Synthesis, Biological Evaluation and Docking Study of Some Novel Isoxazole Clubbed 1,3,4-Oxadiazoles Derivatives,” Medicinal Chemistry Research 27, no. 4 (2018): 1283–91. doi: 10.1007/s00044-018-2148-2.
   Web of Science ®Google Scholar
• Aldo Andreani, Massimiliano Granaiola, Alberto Leoni, Alessandra Locatelli, Rita Morigi, and Mirella Rambaldi, “Synthesis and Antitubercular Activity of Imidazo [2,1-b]Thiazoles,” European Journal of Medicinal Chemistry 36, no. 9 (2001): 743–6.
   PubMed Web of Science ®Google Scholar
• M. A. Abu-Zaied, G. A. M. Nawwar, R. H. Swellem, and S. H. El-Sayed, “Synthesis and Screening of New 5-Substituted-1,3,4-Oxadiazole-2thioglycosides as Potent Anticancer Agents,” Pharmacology and Pharmacy 3 (2012): 254–61.
   Google Scholar
• R. Bhutani, D. P. Pathak, G. Kapoor, A. Husain, R. Kant, and M. A. Iqbal, “Synthesis, Molecular Modelling Studies and ADME Prediction of Benzothiazole Clubbed oxadiazole-Mannich Bases, and Evaluation of Their anti-Diabetic Activity through in Vivo Model,” Bioorganic Chemistry 77 (2018): 6–15.
   PubMed Web of Science ®Google Scholar
• M. Kouhkan, F. Karimi, A. Souldozi, and J. Rashedi, “In Vitro Antimicrobial Activity of New Substituted 1,3,4-Oxadiazole Derivatives,” International Journal of Advanced Research 5, no. 5 (2017): 1468–74.
   Google Scholar
• N. Mihailovic, V. Markovic, I. Z. Matic, N. S. Stanisavljevic, Z. S. Jovanovic, S. Trifunovic, and L. Joksovic, “Synthesis and Antioxidant Activity of 1,3,4-Oxadiazoles and Their Diacylhydrazine Precursors Derived from Phenolic Acids,” RSC Advances 7 (2017): 8550.
   Web of Science ®Google Scholar
• M. A. Bhat, M. A. Al-Omar, and N. Siddiqui, “Synthesis, Anticonvulsant and Neurotoxicity of Some Novel 1,3,4-Oxadiazole Derivatives of Phthalimide,” Der Pharma Chemica 2, no. 2 (2010): 1–10.
   Google Scholar
• H. S. Abd-Ellah, M. A. Aziz, M. E. Shoman, E. A. M. Beshr, T. S. Kaoud, and A. F. F. Ahmed, “Novel 1,3,4-Oxadiazole/Oxime Hybrids: Synthesis, Docking Studies and Investigation of Anti-Inflammatory, Ulcerogenic Liability and Analgesic Activities,” Bioorganic Chemistry 69 (2016): 48–63.
   PubMed Web of Science ®Google Scholar
• F. A. Attaby, A. M. A. Fattah, L. M. Shaif, and M. M. Elsayed, “Anti-Alzheimer and anti-Cox-2 Activities of the Newly Synthesized 2,3-Bipyridine Derivatives (ii), Phosphorus Sulfur Silicon,” Phosphorus, Sulfur, and Silicon and the Related Elements 185, no. 3 (2010): 668–79.
   Web of Science ®Google Scholar
• W. A. El-Sayed, F. A. El-Essawy, O. M. Ali, B. S. Nasr, M. M. Abdalla, and A. A. H. Abdel-Rahman, “Synthesis and Antiviral Evaluation of New 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives and Their Acyclic Nucleoside Analogues,” Monatshefte Für Chemie - Chemical Monthly 141, no. 9 (2010): 1021–8.
   Google Scholar
• V. Malhotra, S. R. Pathak, R. Nath, D. Mukherjee, and K. Shanker, “Substituted Imidazole Derivatives as Novel Cardiovascular Agents,” Bioorganic and Medicinal Chemistry Letters 21, no. 3 (2011): 936–9.
   PubMed Web of Science ®Google Scholar
• N. S. Chandrasekera, M. A. Bailey, M. Files, T. Alling, S. K. Florio, J. Ollinger, J. O. Odingo, and T. Parish, “Synthesis and Anti-Tubercular Activity of 3-Substituted Benzo[b]Thiophene-1,1-Dioxides,” PeerJ 2 (2014): e612. doi: 10.7717/peerj.612.
   PubMed Web of Science ®Google Scholar
• C. Ranjan, J. Kumar, K. Sharma, M. Akhter, A. A. Siddiqui, and G. Chawla, “1, 2, 4-Oxadiazole Incorporated Ketoprofen Analogues in Search of Safer Non-Steroidal anti-Inflammatory Agents: Design, Syntheses, Biological Evaluation and Molecular Docking Studies,” Letters in Drug Design & Discovery 15, no. 6 (2018): 590–601.
   Web of Science ®Google Scholar
• C. Zhao, and Z. Q. Liu, “Diaryl-1,2,4-Oxadiazole Antioxidants: Synthesis and Properties of Inhibiting the Oxidation of DNA and Scavenging Radicals,” Biochimie 95, no. 4 (2013): 842–9.
   PubMed Web of Science ®Google Scholar
• L. L. Xu, T. Liu, L. Wang, L. Li, Y. F. Wu, C. C. Li, B. Di, Q. D. You, and Z. Y. Jiang, “3-(1H-Benzo[d]Imidazol-6-yl)-5-(4-Fluorophenyl)-1,2,4-Oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation,” Oxidative Medicine and Cellular Longevity 2018 (2018): 1–16. doi: 10.1155/2018/3271617.
   Web of Science ®Google Scholar
• C. Krishna, M. V. Bhargavi, C. P. Rao, and G. L. D. Krupadanam, “Synthesis and Antimicrobial Assessment of Novel Coumarins Featuring 1,2,4-Oxadiazole,” Medicinal Chemistry Research 24, no. 10 (2015): 3743–51.
   Web of Science ®Google Scholar
• P. A. Majid, P. J. DeFeyter, E. E. Van der Wall, R. Wardeh, and J. P. Roos, “Molsidomine in the Treatment of Patients with Angina Pectoris: Acute Effects and Clinical Efficacy,” The New England Journal of Medicine 302, no. 1 (1980): 1–6.
   PubMed Web of Science ®Google Scholar
• V. G. Yashunskii, and L. E. Kholodov, “The Chemistry of Sydnone Imines,” Russian Chemical Reviews 49, no. 1 (1980): 28–35.
   Google Scholar
• A. I. Machula, and N. K. Barkor, “Visual Discrimination Characteristics under the Action of Psychostimulants,” Farma Kol Toksikol 43 (1980): 16–21.
   PubMedGoogle Scholar
• H. Cerecetto, and W. Porcal, “Pharmacological Properties of Furoxans and Benzofuroxans: recent Developments,” Mini Reviews in Medicinal Chemistry 5, no. 1 (2005): 57–71.
   PubMed Web of Science ®Google Scholar
• C. R. Mortarini, and V. Gasco, “Antimicrobial Properties of Some Furazan and Furoxan Derivatives,” European Journal of Medicinal Chemistry·15 (1980): 485–7.
   Web of Science ®Google Scholar
• P. Kushwah, D. Mehta, G. K. Gupta, R. Das, and K. Kaur, “A Brief Review on Oxadiazole as a Potent Anticancer Agent,” Inventi Rapid: Med Chem 2013 (2013): 4.
   Google Scholar
• D. S. Musmade, S. R. Pattan, and M. S. Yalgatti, “Oxadiazole a Nucleus with Versatile Biological Behavior,” Indian Journal of Pharmaceutical Education and Research 05, no. 01 (2015): 11–20.
   Google Scholar
• A. K. Singh, V. K. Sahu, and D. Yadav, “Biological Activities of 2, 5-Disubstituted-1, 3, 4-Oxadiazoles. International Journal of Pharma Sciences and Research 2, no. 6 (2011): 135–47.
   Google Scholar
• M. D. Altıntop, B. Sever, G. A. Çiftçi, G. Turan-Zitouni, Z. A. Kaplancıklı, and A. Özdemir, “A. Design, Synthesis, In Vitro and In Silico Evaluation of a New Series of Oxadiazole Based Anticancer Agents as Potential Akt and FAK Inhibitors,” European Journal of Medicinal Chemistry 18 (2018): 328–45. doi: 10.1016/j.ejmech.2018.06.049.
   Google Scholar
• S. Bajaj, P. P. Roy, and J. Singh, “Synthesis, Thymidine Phosphorylase Inhibitory and Computational Study of Novel 1,3,4-Oxadiazole-2-Thione Derivatives as Potential Anticancer Agents,” Computational Biology and Chemistry 76 (2018): 151–60. doi: 10.1016/j.compbiolchem.2018.05.013.
   PubMed Web of Science ®Google Scholar
• G. Verma, G. Chashoo, A. Ali, M. F. Khan, W. Akhtar, I. Ali, M. Akhtar, M. M. Alam, and M. Shaquiquzzaman, “Synthesis of Pyrazole Acrylic Acid Based Oxadiazole and Amide Derivatives as Antimalarial and Anticancer Agents,” Bioorganic Chemistry 77 (2018): 106–24.
   PubMed Web of Science ®Google Scholar
• Leyla Yurttaş, Betül K. Çavuşoğlu, Gülşen A. Çiftçi, and Halide E. Temel, “Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors,” Anti-Cancer Agents in Medicinal Chemistry 18, no. 6 (2018): 914–21.
   PubMed Web of Science ®Google Scholar
• C. D. Mohan, N. C. Anilkumar, S. Rangappa, M. K. Shanmugam, S. Mishra, A. Chinnathambi, S. A. Alharbi, A. Bhattacharjee, G. Sethi, A. P. Kumar, et al. “Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting nF-κB in Hepatocellular Carcinoma Cells,” Frontiers in Oncology (2018). doi: 10.3389/fonc.2018.00042.
   PubMed Web of Science ®Google Scholar
• B. Madhavilatha, D. Bhattacharjee, G. Sabitha, B. V. S. Reddy, J. S. Yadav, N. Nishant Jain, and B. J. M. Reddye, “Synthesis and in Vitro Anticancer Activity of Novel 1,3,4-Oxadiazole-Linked 1,2,3-Triazole/Isoxazole Hybrids,” Journal of Heterocyclic Chemistry (2018). doi: 10.1002/jhet.3110.
   Google Scholar
• B. Chakrapani, V. Ramesh, G. Pourna Chander Rao, D. Ramachandran, T. Madhukar Reddy, A. Kalyan Chakravarthy, and Gattu Sridhar, “Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Linked Imidazothiadiazole Derivatives,” Russian Journal of General Chemistry 88, no. 5 (2018): 1020–4.
   Web of Science ®Google Scholar
• W. Gu, X. Y. Jin, D. D. Li, S. F. Wang, X. B. Tao, and H. Chen, “Design, Synthesis and in Vitro Anticancer Activity of Novel Quinoline and Oxadiazole Derivatives of Ursolic Acid,” Bioorganic and Medicinal Chemistry Letters 27, no. 17 (2017): 4128–32. doi: 10.1016/j.bmcl.2017.07.033.
   PubMed Web of Science ®Google Scholar
• Sébastien Moniot, Mariantonietta Forgione, Alessia Lucidi, Gebremedhin S. Hailu, Angela Nebbioso, Vincenzo Carafa, Francesca Baratta, Lucia Altucci, Nicola Giacché, Daniela Passeri, et al. “Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity,” Journal of Medicinal Chemistry 60, no. 6 (2017): 2344–60.
   PubMed Web of Science ®Google Scholar
• Jarosław Sławiński, Krzysztof Szafrański, Aneta Pogorzelska, Beata Żołnowska, Anna Kawiak, Katarzyna Macur, Mariusz Belka, and Tomasz Bączek, “Novel 2-Benzylthio-5-(1,3,4-Oxadiazol-2-yl)Benzenesulfonamides with Anticancer Activity: Synthesis, QSAR Study, and Metabolic Stability,” European Journal of Medicinal Chemistry 132 (2017): 236–48.
   PubMed Web of Science ®Google Scholar
• Fatma A. F. Ragab, Sahar M. Abou-Seri, Salah A. Abdel-Aziz, Abdallah M. Alfayomy, and Mohamed Aboelmagd, “Design, Synthesis and Anticancer Activity of New Monastrol Analogues Bearing 1,3,4-Oxadiazole Moiety,” European Journal of Medicinal Chemistry 138 (2017): 140–51. doi: 10.1016/j.ejmech.2017.06.026.
   PubMed Web of Science ®Google Scholar
• S. Madhavi, R. Sreenivasulu, and R. R. Raju, “Synthesis and Biological Evaluation of Oxadiazole Incorporated Ellipticine Derivatives as Anticancer Agents,” Monatshefte Für Chemie - Chemical Monthly 148, no. 5 (2017): 933–8. doi: 10.1007/s00706-016-1790-y.
   Google Scholar
• S. P. Ghag and C. R. Kamath, “Synthesis and Anticancer Activity of Some Novel 1, 3, 4-Oxadiazole Compounds of 5-Amino Pyrazole,” International Journal of Advances in Science Engineering and Technology 5, no. 3 (2017): 52–6.
   Google Scholar
• A. Özdemir, B. Sever, M. D. Altıntop, H. E. Temel, O. Atlı, M. Baysal, and F. Demirci, “Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9,” Molecules 22, no. 7 (2017): 1109.
   Web of Science ®Google Scholar
• Nalini Yadav, Parveen Kumar, Aruna Chhikara, and Madhu Chopra, “Development of 1,3,4-Oxadiazole Thione Based Novel Anticancer Agents: Design, Synthesis and In-Vitro Studies,” Biomedicine and Pharmacotherapy 95 (2017): 721–30.
   PubMed Web of Science ®Google Scholar
• J. D. S. Chaves, L. G. Tunes, C. H. D. J. Franco, T. M. Francisco, C. C. Corrêa, S. M. F. Murta, R. L. Monte-Neto, H. Silva, A. P. S. Fontes, and M. V. D. Almeida, “Novel Gold(I) complexes with 5-Phenyl-1,3,4-Oxadiazole-2-Thione and Phosphine as Potential Anticancer and Antileishmanial Agents,” European Journal of Medicinal Chemistry 127, (2017): 727–39. doi: 10.1016/j.ejmech.2016.10.052.
   PubMed Web of Science ®Google Scholar
• F. Porta, G. Facchetti, N. Ferri, A. Gelain, F. Meneghetti, S. Villa, D. Barlocco, D. Masciocchi, A. Asai, N. Miyoshi, et al. “An In Vivo Active 1,2,5-Oxadiazole Pt(II) Complex: A Promising Anticancer Agent Endowed with STAT3 Inhibitory Properties,” European Journal of Medicinal Chemistry 131 (2017): 196–206. doi: 10.1016/j.ejmech.2017.03.017.
   PubMed Web of Science ®Google Scholar
• A. V. S. Rao, M. V. P. S. V. Vardhan, N. V. S. Reddy, T. S. Reddy, S. P. Shaik, C. Bagul, and A. Kamal, “Synthesis and Biological Evaluation of Imidazopyridinyl-1,3,4-Oxadiazole Conjugates as Apoptosis Inducers and Topoisomerase Iiα Inhibitors,” Bioorganic Chemistry 69 (2016): 7–19.
   PubMed Web of Science ®Google Scholar
• N. R. Kumar, Y. Poornachandra, P. Nagender, G. Santhosh Kumar, D. Krishna Swaroop, C. Ganesh Kumar, and B. Narsaiah, “Synthesis of Novel Nicotinohydrazide and (1,3,4-Oxadiazol-2-yl)-6-(Trifluoro Methyl)Pyridine Derivatives as Potential Anticancer Agents,” Bioorganic and Medicinal Chemistry Letters 26, no. 19 (2016): 4829–31. doi: 10.1016/j.bmcl.2016.08.020.
   PubMed Web of Science ®Google Scholar
• A. Kamal, P. S. Srikanth, M. V. P. S. Vishnuvardhan, G. B. Kumar, M. K. S. Babu, S. M. Ali Hussaini, J. S. Kapure, and A. Alarifi, “Combretastatin Linked 1,3,4-Oxadiazole Conjugates as a Potent Tubulin Polymerization Inhibitors,” Bioorganic Chemistry 65 (2016): 126–36. doi: 10.1016/j.bioorg.2016.02.007.
   PubMed Web of Science ®Google Scholar
• M. Agarwal, V. Singh, S. K. Sharma, P. Sharma, M. Y. Ansari, S. S. Jadav, S. Yasmin, R. Sreenivasulu, M. Z. Hassan, V. Saini, et al. “Design and Synthesis of New 2,5-Disubstituted-1,3,4-Oxadiazole Analogues as Anticancer Agents,” Medicinal Chemistry Research 25, no. 10 (2016): 2289–303. doi: 10.1007/s00044-016-1672-1.
   Web of Science ®Google Scholar
• J. J. Zhao, X. F. Wang, B. L. Li, R. L. Zhang, B. Li, Y. M. Liu, C. W. Li, J. B. Liu, and B. Q. Chen, “Synthesis and in Vitro Antiproliferative Evaluation of Novel Nonsymmetrical Disulfides Bearing 1,3,4-Oxadiazole Moiety,” Bioorganic and Medicinal Chemistry Letters 26, no. 18 (2016): 4414–6. doi: 10.1016/j.bmcl.2016.08.014.
   PubMed Web of Science ®Google Scholar
• B. Mochona, X. Qi, S. Euynni, D. Sikazwi, N. Mateeva, and K. F. Soliman, “Design and Evaluation of Novel Oxadiazole Derivatives as Potential Prostate Cancer Agents,” Bioorganic and Medicinal Chemistry Letters (2016).
   PubMedGoogle Scholar
• Mei Han, Shan Li, Jing Ai, Rong Sheng, Yongzhou Hu, Youhong Hu, and Meiyu Geng, “Discovery of 4-Chloro-3-(5-(Pyridin-3-yl)-1,2,4-Oxadiazole-3-yl)Benzamides as Novel RET Kinase Inhibitors,” Bioorganic and Medicinal Chemistry Letters 26, no. 23 (2016): 5679–84.
   PubMed Web of Science ®Google Scholar
• S. Rubino, I. Pibiri, C. Costantino, S. Buscemi, M. A. Girasolo, A. Attanzio, and L. Tesoriere, “Synthesis of Platinum Complexes with 2-(5-Perfluoroalkyl-1,2,4-Oxadiazol-3yl)-Pyridine and 2-(3-Perfluoroalkyl-1-Methyl-1,2,4-Triazole-5yl)-Pyridine Ligands and Their in Vitro Antitumor Activity,” Journal of Inorganic Biochemistry 155 (2016): 92–100.
   PubMed Web of Science ®Google Scholar
• C. V. Maftei, E. Fodor, P. G. Jones, C. G. Daniliuc, M. H. Franz, G. Kelter, H. H. Fiebig, M. Tamm, and I. Neda, “Novel 1,2,4-Oxadiazoles and Trifluoromethylpyridines Related to Natural Products: Synthesis, Structural Analysis and Investigation of Their Antitumor Activity,” Tetrahedron 72, no. 9 (2016): 1185–99. doi: 10.1016/j.tet.2016.01.011.
   Web of Science ®Google Scholar
• Y.-T. Li, J. H. Wang, C. W. Pan, F. F. Meng, X. Q. Chu, Y. H. Ding, W. Z. Qu, H. Y. Li, C. Yang, Q. Zhang, et al. “Syntheses and Biological Evaluation of 1,2,3-Triazole and 1,3,4-Oxadiazole Derivatives of Imatinib,” Bioorganic and Medicinal Chemistry Letters 26, no. 5 (2016): 1419–27. doi: 10.1016/j.bmcl.2016.01.068.
   PubMed Web of Science ®Google Scholar
• Shamsuzzaman, T. Siddiqui, M. G. Alam, and A. Mahmood Dar, “Synthesis, Characterization and Anticancer Studies of New Steroidal Oxadiazole, Pyrrole and Pyrazole Derivatives,” Journal of Saudi Chemical Society 19 (2015): 387–91.
   Web of Science ®Google Scholar
• M. M. Gamal El-Din, M. I. El-Gamal, M. S. Abdel-Maksoud, K. H. Yoo, and C. H. Oh, “Synthesis and in Vitro Antiproliferative Activity of New 1,3,4-Oxadiazole Derivatives Possessing Sulfonamide Moiety,” European Journal of Medicinal Chemistry 90 (2015): 45–52.
   PubMed Web of Science ®Google Scholar
• M. Rashid, A. Husain, R. Mishra, S. Karim, S. Khan, M. Ahmad, N. Al-Wabel, A. Husain, A. Ahmad, and S. A. Khan, “Design and Synthesis of Benzimidazoles Containing Substituted Oxadiazole, Thiadiazole and Triazolo-Thiadiazines as a Source of New Anticancer Agents,” Arabian Journal of Chemistry 12, no. 8 (2019): 3202–24. doi: 10.1016/j.arabjc.2015.08.019.
   Web of Science ®Google Scholar
• B. Yadagiri, S. Gurrala, R. Bantu, L. Nagarapu, S. Polepalli, G. Srujana, and N. Jain, “Synthesis and Evaluation of Benzosuberone Embedded with 1,3,4-Oxadiazole, 1,3,4-Thiadiazole and 1,2,4-Triazole Moieties as New Potential Anti Proliferative Agents,” Bioorganic and Medicinal Chemistry Letters 25, no. 10 (2015): 2220–4. doi: 10.1016/j.bmcl.2015.03.032.
   PubMed Web of Science ®Google Scholar
• N. M. Sankhe, E. Durgashivaprasad, N. G. Kutty, J. V. Rao, K. Narayanan, N. Kumar, P. Jain, N. Udupa, and P. V. Raj, “Novel 2,5-Disubstituted-1,3,4-Oxadiazole Derivatives Induce Apoptosis in HepG2 Cells through p53 Mediated Intrinsic Pathway,” Arabian Journal of Chemistry 12, no. 8 (2019): 2548–55. doi: 10.1016/j.arabjc.2015.04.030.
   Web of Science ®Google Scholar
• A. Kamal, T. S. Reddy, M. V. P. S. Vishnuvardhan, K. Nimbarte, A. V. S. Rao, V. Srinivasulu, and N. Shankaraiah, “Synthesis of 2-Aryl-1,2,4-Oxadiazolo-Benzimidazoles: Tubulin Polymerization Inhibitors and Apoptosis Inducing Agents,” Bioorganic and Medicinal Chemistry 23, no. 15 (2015): 4608–23. doi: 10.1016/j.bmc.2015.05.060.
   PubMed Web of Science ®Google Scholar
• M. Al-Ghorbani, V. Vigneshwaran, V. L. Ranganatha, B. T. Prabhakar, and S. A. Khanum, “Synthesis of Oxadiazole-Morpholine Derivatives and Manifestation of the Repressed CD31 Microvessel Density (MVD) as Tumoral Angiogenic Parameters in Dalton's Lymphoma,” Bioorganic Chemistry 60 (2015): 136–46. doi: 10.1016/j.bioorg.2015.04.008.
   PubMed Web of Science ®Google Scholar
• Catalin V. Maftei, Elena Fodor, Peter G. Jones, Matthias Freytag, M. Heiko Franz, Gerhard Kelter, Heinz-Herbert Fiebig, Matthias Tamm, and Ion Neda, “Carbenes (NHC) with 1,2,4-Oxadiazole-Substituents Related to Natural Products: Synthesis, Structure and Potential Antitumor Activity of Some Corresponding Gold(I) and Silver(I) Complexes,” European Journal of Medicinal Chemistry 101 (2015): 431–41. doi: 10.1016/j.ejmech.2015.06.053.
   PubMed Web of Science ®Google Scholar
• J. Cai, H. Wei, K. H. Hong, X. Wu, M. Cao, X. Zong, L. Li, C. Sun, J. Chen, and M. Ji, “Discovery and Preliminary Evaluation of 2-Aminobenzamide and Hydroxamate Derivatives Containing 1,2,4-Oxadiazole Moiety as Potent Histone Deacetylase Inhibitors,” European Journal of Medicinal Chemistry 96 (2015): 1–13. doi: 10.1016/j.ejmech.2015.04.002.
   PubMed Web of Science ®Google Scholar
• M. M. Gamal El-Din, M. I. El-Gamal, M. S. Abdel-Maksoud, K. H. Yoo, and C. H. Oh, “Synthesis and Broad-Spectrum Antiproliferative Activity of Diarylamides and Diarylureas Possessing 1,3,4-Oxadiazole Derivatives,” Bioorganic and Medicinal Chemistry Letters 25, no. 8 (2015): 1692–9. doi: 10.1016/j.bmcl.2015.03.001.
   PubMed Web of Science ®Google Scholar
• C. K. Thasneem, C. R. Biju, and G. Babu, “Synthesis and Anticancer Study of Chalcone Linked 1, 3, 4-Oxadiazole Derivatives,” International Journal of Pharma and Bio Sciences 4, no. 4 (2014): 20–8.
   Google Scholar
• Ahmed Kamal, Anver Basha Shaik, Sowjanya Polepalli, Vangala Santosh Reddy, G. Bharath Kumar, Soma Gupta, K. V. S. Rama Krishna, Ananthamurthy Nagabhushana, Rakesh K. Mishra, and Nishant Jain, “Pyrazole-oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization,” Organic and Biomolecular Chemistry 12, no. 40 (2014): 7993–8007.
   PubMed Web of Science ®Google Scholar
• M. J. Ahsan, J. Sharma, M. Singh, S. S. Jadav, and S. Yasmin, “Synthesis and Anticancer Activity of N-Aryl-5-Substituted-1,3,4-Oxadiazol-2-Amine Analogues,” BioMed Research International 2014 (2014): 814984. doi: 10.1155/2014/814984.
   PubMed Web of Science ®Google Scholar
• V. Adimule, Sudha Medapa, A. H. Jagadeesha, L. S. Kumar, and P. K. Rao, “Synthesis, Characterization and in Vitro Anticancer Properties of 1-{5-Aryl-2-[5-(4-Fluoro-Phenyl)-Thiophen-2-yl]-[1,3,4]Oxadiazol-3-yl}-Ethanone,” International Journal of Pharma Research and Review 3, no. 12 (2014): 20–5.
   Google Scholar
• Yaşar Dürüst, Hamza Karakuş, Muhsine Zeynep Yavuz, and Ali Akçahan Gepdiremen, “Synthesis of Novel Triazoles Bearing 1,2,4-Oxadiazole and Phenylsulfonyl Groups by 1,3-Dipolar Cycloaddition of Some Organic Azides and Their Biological Activities,” Turkish Journal of Chemistry 38 (2014): 739–55.
   Web of Science ®Google Scholar
• V. Girish, N. D. Rekha, V. L. Ranganatha, S. N. Manjula, and S. A. Khanum, “Synthesis and Evaluation of Antiangiogenic and Anticancer Properties of Novel Oxadiazole Analogues,” International Research Journal of Pharmacy 5, no. 6 (2014): 489–94.
   Google Scholar
• V. Adimule, Sudha Medapa, A. H. Jagadeesha, L. S. Kumar, and P. K. Rao, “Synthesis, Characterization and Cytotoxic Evaluation of Novel Derivatives of 1, 3, 4-Oxadiazole Containing 5-Phenyl Thiophene Moiety,” IOSR Journal of Pharmacy and Biological Sciences 9, no. 5 (2014): 42–8.
   Google Scholar
• K. Zhang, P. Wang, L. N. Xuan, X. Y. Fu, F. Jing, S. Li, Y. M. Liu, and B. Q. Chen, “Synthesis and Antitumor Activities of Novel Hybrid Molecules Containing 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Bearing Schiff Base Moiety,” Bioorganic and Medicinal Chemistry Letters 24, no. 22 (2014): 5154–6. doi: 10.1016/j.bmcl.2014.09.086.
   PubMed Web of Science ®Google Scholar
• B. N. P. Kumar, K. N. Mohana, L. Mallesha, and B. Veeresh, “Synthesis and in Vitro Antiproliferative Activity of 2,5-Disubstituted-1,3,4-Oxadiazoles Containing Trifluoromethyl Benzenesulfonamide Moiety,” Medicinal Chemistry Research 23, no. 7 (2014): 3363–73. doi: 10.1007/s00044-014-0918-z.
   Web of Science ®Google Scholar
• S. Valente, D. Trisciuoglio, T. D. Luca, A. Nebbioso, Labella Donatella, Alessia Lenoci, A. Bigogno, C. Dondio, G. Miceli, M. Brosch, et al. “1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells,” Journal of Medicinal Chemistry 57, no. 14 (2014): 6259–65.
   PubMed Web of Science ®Google Scholar
• F. Zhang, X. L. Wang, J. Shi, S. F. Wang, Y. Yin, Y. S. Yang, W. M. Zhang, and H. L. Zhu, “Synthesis, Molecular Modeling and Biological Evaluation of N-Benzylidene-2-((5-(Pyridin-4-yl)-1,3,4-Oxadiazol-2-yl)Thio)Acetohydrazide Derivatives as Potential Anticancer Agents,” Bioorganic and Medicinal Chemistry 22, no. 1 (2014): 468–77. doi: 10.1016/j.bmc.2013.11.004.
   PubMed Web of Science ®Google Scholar
• Sohail Anjum Shahzad, Muhammad Yar, Marek Bajda, Bushra Jadoon, Zulfiqar Ali Khan, Syed Ali Raza Naqvi, Ahson Jabbar Shaikh, Khizar Hayat, Adeem Mahmmod, Nasir Mahmood, et al. “Synthesis and Biological Evaluation of Novel Oxadiazole Derivatives: A New Class of Thymidine Phosphorylase Inhibitors as Potential anti-Tumor Agents,” Bioorganic and Medicinal Chemistry 22, no. 3 (2014): 1008–15.
   PubMed Web of Science ®Google Scholar
• J. Sun, M. H. Li, S. S. Qian, F. J. Guo, X. F. Dang, X. M. Wang, Y. R. Xue, and H. L. Zhu, “Synthesis and Antitumor Activity of 1,3,4-Oxadiazole Possessing 1,4-Benzodioxan Moiety as a Novel Class of Potent Methionine Aminopeptidase Type II Inhibitors,” Bioorganic and Medicinal Chemistry Letters 23, no. 10 (2013): 2876–9. doi: 10.1016/j.bmcl.2013.03.068.
   PubMed Web of Science ®Google Scholar
• M. P. Tantak, A. Kumar, B. Noel, K. Shah, and D. Kumar, “Synthesis and Biological Evaluation of 2-Arylamino-5- (3'-Indolyl)-1,3,4-Oxadiazoles as Potent Cytotoxic Agents,” ChemMedChem 8, no. 9 (2013): 1468–74. doi: 10.1002/cmdc.201300221.
   PubMed Web of Science ®Google Scholar
• P. Miralinaghi, M. Salimi, A. Amirhamzeh, M. Norouzi, H. M. Kandelousi, A. Shafiee, and M. Amini, “Synthesis, Molecular Docking Study, and Anticancer Activity of Triaryl-1,2,4-Oxadiazole,” Medicinal Chemistry Research 22, no. 9 (2013): 4253–62.
   Web of Science ®Google Scholar
• Salahuddin, M. Shaharyar, A. Mazumder, and M. J. Ahsan, “Synthesis, Characterization and Anticancer Evaluation of 2-(Naphthalen-1-Ylmethyl/Naphthalen-2-Yloxymethyl)-1-[5-(Substituted Phenyl)-1,3,4]Oxadiazol-2-Ylmethyl]-1Hbenzimidazole,” Arabian Journal of Chemistry 7, no. 4 (2013): 418–24. doi: 10.1016/j.arabjc.2013.02.001.
   Web of Science ®Google Scholar
• Khalid Mohammed Khan, Mubeen Rani, Nida Ambreen, Muhammad Ali, Sajjad Hussain, Shahnaz Perveen, and Muhammad Iqbal Choudhary, “Choudhary, 2,5-Disubstituted-1,3,4-Oxadiazoles: Thymidine Phosphorylase Inhibitors,” Medicinal Chemistry Research 22, no. 12 (2013): 6022–8. doi: 10.1007/s00044-013-0588-2.
   Web of Science ®Google Scholar
• R. R. Somani, S. Chiplunkar, S. P. Vetale, D. T. Makhija, and P. Y. Shirodkar, “Evaluation of Apoptosis Inducing Activity of an Oxadiazole Based Potential Anticancer Compound,” International Journal of PharmTech Research 5, no. 3 (2013): 1233–40.
   Google Scholar
• C. V. Maftei, E. Fodor, P. G. Jones, M. H. Franz, G. Kelter, H. Fiebig, and I. Neda, “Synthesis and Characterization of Novel Bioactive 1,2,4-Oxadiazole Natural Product Analogs Bearing the N-Phenylmaleimide and N-Phenylsuccinimide Moieties,” Beilstein Journal of Organic Chemistry 9 (2013): 2202–15.
   PubMed Web of Science ®Google Scholar
• M. Rashid, A. Husain, and R. Mishra, “Synthesis of Benzimidazoles Bearing Oxadiazole Nucleus as Anticancer Agents,” European Journal of Medicinal Chemistry 54 (2012): 855–66.
   PubMed Web of Science ®Google Scholar
• A. Husain, M. Rashid, R. Mishra, S. Parveen, D. S. Shin, and D. Kumar, “Benzimidazole Bearing Oxadiazole and Triazolo-Thiadiazoles Nucleus: Design and Synthesis as Anticancer Agents,” Bioorganic and Medicinal Chemistry Letters 22, no. 17 (2012): 5438–44.
   PubMed Web of Science ®Google Scholar
• S. Bondock, S. Adel, H. A. Etman, and F. A. Badria, “Synthesis and Antitumor Evaluation of Some New 1,3,4-Oxadiazole-Based Heterocycles,” European Journal of Medicinal Chemistry 48, (2012): 192–9.
   PubMed Web of Science ®Google Scholar
• G. L. Khatik, J. Kaur, V. Kumar, K. Tikoo, and V. A. Nair, “1,2,4-Oxadiazoles: A New Class of Anti-Prostate Cancer Agents,” Bioorganic and Medicinal Chemistry Letters 22, no. 5 (2012): 1912–6.
   PubMed Web of Science ®Google Scholar
• P. Puthiyapurayil, B. Poojary, C. Chikkanna, and S. K. Buridipad, “Design, Synthesis and Biological Evaluation of a Novel Series of 1,3,4-Oxadiazole Bearing N-Methyl-4-(Trifluoromethyl)Phenyl Pyrazole Moiety as Cytotoxic Agents,” European Journal of Medicinal Chemistry 53 (2012): 203–10.
   PubMed Web of Science ®Google Scholar
• K. Liu, X. Lu, H. J. Zhang, J. Sun, and H. L. Zhu, “Synthesis, Molecular Modeling and Biological Evaluation of 2-(Benzylthio)-5-Aryloxadiazole Derivatives as anti-Tumor Agents,” European Journal of Medicinal Chemistry 47, no. 1 (2012): 473–8.
   PubMedGoogle Scholar
• R. Kotla, A. C. Murugulla, R. Ruddarraju, M. V. B. Rao, P. Aparna, and S. Donthabakthuni, “Synthesis and Biological Evaluation of 1,3,4-Oxadiazole Fused Tetrazole Amide Derivatives as Anticancer Agents,” Chemical Data Collections 30 (2020): 100548.
   Google Scholar
• A. T. Taher, H. H. Georgey, and H. I. El-Subbagh, “Novel 1,3,4-Heterodiazole Analogues: Synthesis and In-Vitro Antitumor Activity,” European Journal of Medicinal Chemistry 47, no. 1 (2012): 445–51.
   PubMedGoogle Scholar
• Y. Hu, X. Lu, K. Chen, R. Yan, Q. S. Li, and H. L. Zhu, “Design, Synthesis, Biological Evaluation and Molecular Modeling of 1,3,4-Oxadiazoline Analogs of combretastatin-A4 as Novel Antitubulin Agents,” Bioorganic and Medicinal Chemistry 20, no. 2 (2012): 903–9.
   PubMed Web of Science ®Google Scholar
• Jie Ren, Lin Wu, Wen Qun Xin, Xin Chen, and Kun Hu, “Synthesis and Biological Evaluation of Novel 4b-(1,3,4-Oxadiazole-2-Amino)-Podophyllotoxin Derivatives,” Bioorganic and Medicinal Chemistry Letters 22, no. 14 (2012): 4778–82.
   PubMed Web of Science ®Google Scholar
• Parsharamulu Rayam, Naveen Polkam, Naveen Kuntala, Venkanna Banothu, Hasitha Shilpa Anantaraju, Yogeeswari Perumal, Sridhar Balasubramanian, and Jaya Shree Anireddy, “Design and Synthesis of Oxaprozin-1,3,4-Oxadiazole Hybrids as Potential Anticancer and Antibacterial Agents,” Journal of Heterocyclic Chemistry 57, no. 3 (2020): 1071–82. doi: 10.1002/jhet.3842.
   Web of Science ®Google Scholar
• Rajyalakshmi Gudipati, Rama Narsimha Reddy Anreddy, and Sarangapani Manda, “Characterization and Anticancer Activity of Certain 3-{4-(5-Mercapto-1,3,4-Oxadiazole-2-yl)Phenylimino}Indolin-2-One Derivatives,” Saudi Pharmaceutical Journal 19, no. 3 (2011): 153–8.
   PubMed Web of Science ®Google Scholar
• B. Madhavilatha, D. Bhattacharjee, G. Sabitha, B. V. S. Reddy, J. S. Yadav, N. Jain, and B. J. M. Reddy, “Synthesis and in Vitro Anticancer Activity of Novel 1,3,4-Oxadiazole-Linked 1,2,3-Triazole/Isoxazole Hybrids,” Journal of Heterocyclic Chemistry 55, no. 4 (2018): 863–70.
   Web of Science ®Google Scholar
• M. K. Abd el Hameid, and M. R. Mohammed, “Design, Synthesis, and Cytotoxicity Screening of 5-Aryl-3-(2-(Pyrrolyl) Thiophenyl)-1, 2, 4-Oxadiazoles as Potential Antitumor Molecules on Breast Cancer MCF-7 Cells,” Bioorganic Chemistry 86 (2019): 609–23.
   PubMed Web of Science ®Google Scholar
• A. Radin, R. A. Nima, R. Ali, and H. Zahra, “Insights into the Structural/Conformational Requirements of Cytotoxic Oxadiazoles as Potential Chemotherapeutic Target Binding Agents,” Journal of Molecular Structure 1164 (2018): 9–22.
   Web of Science ®Google Scholar
• A.-E. El Mansouri, A. Oubella, M. Maatallah, M. Youssef AitItto, Z. Mohamed, H. Morjani, and H. B. Lazrek, “Design, Synthesis, Biological Evaluation and Molecular Docking of New Uracil Analogs-1,2,4-Oxadiazole Hybrids as Potential Anticancer Agents,” Bioorganic and Medicinal Chemistry Letters (2020).
   PubMedGoogle Scholar
• H. D. Gurupadaswamy, V. Girish, C. V. Kavitha, S. C. Raghavan, and S. A. Khanum, “Synthesis and Evaluation of 2,5-Di(4-Aryloylaryloxymethyl)-1,3,4-Oxadiazoles as Anti-cancer Agents,” European Journal of Medicinal Chemistry 63 (2013): 536–43.
   PubMed Web of Science ®Google Scholar
• J. Zhang, X. Wang, J. Yang, L. Guo, X. Wang, B. Song, W. Dong, and W. Wang, “Novel Diosgenin Derivatives Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Potential Antitumor Agents: Design, Synthesis and Cytotoxic Evaluation,” European Journal of Medicinal Chemistry. (2019). doi: 10.1016/j.ejmech.2019.111897.
   Web of Science ®Google Scholar
• K. Lakshmithendral, K. Saravanan, R. Elancheran, K. Archana, N. Manikandan, H. A. Arjun, M. Ramanathan, N. K. Lokanath, and S. Kabilan, “Design, Synthesis and Biological Evaluation of 2-(Phenoxymethyl)-5-Phenyl-1,3,4-Oxadiazole Derivatives as Anti-Breast Cancer Agents,” European Journal of Medicinal Chemistry 168 (2019): 1–10.
   PubMed Web of Science ®Google Scholar
• Fatima Naaz, Faiz Ahmad, Bilal Ahmad Lone, Yuba Raj Pokharel, Neeraj Kumar Fuloria, Shivkanya Fuloria, Manickam Ravichandran, Lalitha Pattabhiraman, Syed Shafi, and M. Shahar Yar, “Design and Synthesis of Newer 1,3,4-Oxadiazole and 1,2,4-Triazole Based Topsentin Analogues as anti-Proliferative Agent Targeting Tubulin,” Bioorganic Chemistry 95 (2020): 103519.
   PubMed Web of Science ®Google Scholar
• R. Polothi, G. S. B. Raolji, V. S. Kuchibhotla, K. Sheelam, B. Tuniki, and P. Thodupunuri, “Synthesis and Biological Evaluation of 1,2,4-Oxadiazole Linked 1,3,4-Oxadiazole Derivatives as Tubulin Binding Agents,” Synthetic Communications (2019).
   Web of Science ®Google Scholar
• F. Shamsi, P. Hasan, A. Queen, A. Hussain, P. Khan, B. Zeya, H. M. King, S. Rana, J. Garrison, M. F. Alajmi, et al. “Synthesis and SAR Studies of Novel 1,2,4-Oxadiazole-Sulfonamide Based Compounds as Potential Anticancer Agents for Colorectal Cancer Therapy,” Bioorganic Chemistry 98 (2020): 103754.
   PubMed Web of Science ®Google Scholar
• R. Krishna, G. Sridhar, and H. V. Jayaprakash, “Synthesis and Anticancer Activity of Novel 1,2,3-Triazole Ring Incorporated 1,2,4-Oxadiazole-1,3-Oxazole Derivatives,” Russian Journal of General Chemistry 90, no. 5 (2020): 901–6.
   Web of Science ®Google Scholar
• Y. Ono, M. Ninomiya, D. Kaneko, A. D. Sonawane, T. Udagawa, K. Tanaka, A. Nishina, and M. Koketsu, “Design and Synthesis of Quinoxaline-1,3,4-Oxadiazole Hybrid Derivatives as Potent Inhibitors of the Anti-Apoptotic Bcl-2 Protein,” Bioorganic Chemistry 104 (2020): 104245.
   PubMed Web of Science ®Google Scholar
• N. Perupogu, D. R. Kumar, and D. Ramachandran, “Anticancer Activity of Newly Synthesized 1,2,4-Oxadiazole Linked 4-(Oxazolo[5,4-d]Pyrimidine Derivatives,” Chemical Data Collections 27 (2020): 100363. doi: 10.1016/j.cdc.2020.100363.
   Google Scholar
• Ankur Vaidya, Shweta Jain, Br Prashantha Kumar, Shashank K. Singh, Sushil Kumar Kashaw, and Ram Kishore Agrawal, “Synthesis of 1,2,4-Oxadiazole Derivatives: Anticancer and 3D QSAR Studies,” Monatshefte Für Chemie 151, no. 3 (2020): 385–95. doi: 10.1007/s00706-020-02553-1.
   Web of Science ®Google Scholar