Abstract
Present investigation reported one-pot multicomponent synthesis of novel series of 8-benzyloxy-5-{2-[N′-(1,3-diphenyl-1H-pyrazol-4-ylmethylene)-hydrazino]-thiazol-4-yl}-3,4-dihydro-1H-quinolin-2-one derivatives. The titled compounds were synthesized by using one-pot condensation of substituted 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde, thiosemicarbazide, and 8-benzyloxy-5-(2-bromo-acetyl)-1H-quinolin-2-one. Main features of present protocol are environmentally benign, rapid and good to excellent yield of the products (93–99%).
Graphical Abstract
Acknowledgments
The authors are thankful to Principal, Maulana Azad College Research Centre, Aurangabad for providing library and laboratory facilities for this work.
Disclosure statement
No potential conflict of interest was reported by the author(s).