Rodenticidal Activity of Some Quinoline-Based Heterocycles Derived from Hydrazide–Hydrazone Derivative

Abstract

It was well known that hydrazine–hydrazone derivatives have an important role in different synthetic and medicinal fields. Therefore, the hydrazide–hydrazone derivative 3 was treated with electrophilic reagents achieving some quinoline-based heterocyclic systems such as chromene and pyridine derivatives and screened for their rodenticidal activity. The potent compounds were subjected to density functional theory studies. Seven compounds were tested for hemorrhoidal activity. Compounds 5, 6, and 7 were more effective against rodents than the other synthesized compounds, which were controlled by the most potent active second-generation products, such as chlorophacinone, brodifacoum, and warfarin. This could be attributed to their existence in more tautomeric structures. As a result, they could be used as rodenticides.

Graphical Abstract

Keywords:

• Rodenticide
• anticoagulant
• quinoline
• chromene

Disclosure statement

The authors declare no conflict of interest.