One Pot Approach of Novel Xanthan Perchloric Acid Catalyst in Synthesis of Bis(Indolyl)Methane Derivatives via Greener Perspective

Abstract

A convenient, eco-friendly electrophilic reaction of indole with substituted aromatic aldehydes to yield bis(indolyl)methane (BIM) derivatives. BIM derivatives are synthesized in one pot by employing a biopolymer-derived novel heterogeneous catalyst, Xanthan Perchloric Acid (XPA). The Catalyst XPA is prepared from biopolymer xanthan and treated with perchloric acid. XPA is thermally stable with sufficient acidic sites, mild, nontoxic, and reusable. The reaction proceeds smoothly at room temperature in the green context, shorter reaction time, and excellent yield under solvent-free conditions.

Graphical Abstract

Keywords:

• Biopolymer
• green synthesis
• bis(indolyl)methane
• xanthan perchloric acid

Acknowledgements

The authors are supported by the office bearers of Ahmednagar Jilha Maratha Vidya Prasarak Samaj’s Ahmednagar and New Arts, Commerce and Science College, Parner and Department of Science and Technology (DST), New Delhi for the research facilities. Thanks are due to SAIF, Punjab University, Chandigarh for providing some of the analytical facilities.

Disclosure statement

The authors declare no conflict of interest, financial or otherwise.

Data availability statement

The data that support the findings of this study are openly available in “figshare” at http://doi10.6084/m9.figshare.19575823.

Scheme 1. Synthesis of BIMs under solvent free conditions.