A Brief Review on the Design, Synthesis and Biological Evaluation of Pyrazolo[c]coumarin Derivatives

Abstract

Both pyrazole and coumarin moiety are important scaffolds for their natural occurrences as well as a broad spectrum of pharmaceutical properties. When coumarin fuses with pyrazole containing a diverse functionality, synergic effect may be observed in the field of medicinal and material chemistry. Owing to their various functionality on the pyrazole as well as coumarin moiety of the title compounds, they possess fantastic biological properties including antimicrobial, antiproliferative, CpIMPDH inhibition, α-glucosidase inhibition, selective hCA IX inhibition as well as anticancer activities. Some architectural pyrazolo[c]coumarin derivatives were reported to be used in bipolar host materials and blue TADF-OLEDs. For these reasons, a special attention has been paid to researchers for the searching of new, greener and efficient protocols for the design and synthesis of pyrazolo[c]coumarins to evaluate their biological activities. This paper reviews the research data in the literature on the synthetic strategies for structurally designed pyrazolo[c]coumarin derivatives. Furthermore, the biological properties of these synthesized compounds are described by highlighting their mode of interactions with different cells and enzymes.

Keywords:

• Pyrazolo[c]coumarin
• 34-fused-coumarin
• hydrazine-derivatives
• condensation-cyclization
• anticancer-activity

Acknowledgements

We sincerely thank the Department of Higher Education, Science & Technology and Biotechnology, West Bengal for financial help ((368 (Sanc.)/STBT-11012(25)/11/2020-ST SEC Date 14/07/2021)) and Professor Gandhi Kumar Kar and Dr Pradipta Ghosh for their valuable suggestions for their comments.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Figure 3. Pyrazolo[c]coumarins as benzodiazepine receptor.