Comprehensive Review on One-pot Green Synthesis of Pyran and Chromene Fused Benzo[α]phenazines

Abstract

One of the important classes of aza-polycyclic compounds is Phenazine systems which are naturally present and synthetically derived. More than 6000 phenazine compounds are recognized; among them, pyran and chromene fused Benzo[α]phenazines have gained special attention due to their fascinating biological properties. In this regard, synthesizing these phenazinle derivatives by multicomponent reactions has gained much attention due to the advantages associated with the process. Hence seeing the contribution of pyran and chromene fused benzo phenazines to the pharmaceutical field, this review highlights the synthesis of these compounds by different catalytic conditions involving the use of nontoxic catalysts and solvents in a multicomponent system. This review evaluates studies reported since 2012 on the multicomponent green synthesis of pyran and chromene fused benzo phenazines.

Graphical Abstract

Keywords:

• Benzo[α]phenazines
• pyrano-fused benzo phenazine
• chromene fused benzo phenazine
• multicomponent reaction
• green reactions

Acknowledgement

Authors are thankful to the Chandigarh University for providing the resources for our work.

Disclosure statement

No potential conflict of interest was reported by the author(s).