Use of a New Natural Deep Eutectic Mixture for the Acceleration of Some of the Important Multi-Component Reactions

Abstract

In this study, a new deep eutectic mixture (DEM) was prepared from D-fructose, L-arginine, and urea and characterized by Fourier transform infrared (FT-IR), refractive index measurement, and thermogravimetric analysis (TGA). In continue this mixture was used as a green catalyst to promote the synthesis of three important derivatives of heterocyclic compounds. The highlights of this work include some notable advantages such as ease of the preparation and simple catalytic process, low cost, green reaction conditions, biodegradability of the catalyst, short reaction times, high yields of the products and simple work-up. Also, the catalyst could be recovered easily and reused up to several times without significant loss of catalytic activity.

Graphical Abstract

Keywords:

• D-Fructose
• cyclic β-diketones
• deep eutectic mixture
• 18-Dioxo-decahydroacridines
• Hantzsch condensation
• benzimidazolo quinazolinones
• multi-component reactions

Acknowledgments

The authors have appreciated the Research Council of Guilan University for helping to do this research.

Disclosure statement

No potential conflict of interest was reported by the author(s).