621
Views
27
CrossRef citations to date
0
Altmetric
Review Articles

Advancements in the Analytical Quantification of Nitroxidative Stress Biomarker 3-Nitrotyrosine in Biological Matrices

ORCID Icon, & ORCID Icon
Pages 265-289 | Published online: 08 Jun 2019
 

Abstract

Dysfunction of the antioxidant system or mutations in the gene may result in the elevated production of certain biomarkers. 3-nitrotyrosine (3-NT) is one such promising biomarker of oxidative stress formed due to nitration of protein bound and free tyrosine residues. It has a significant potential to be exploited for the early diagnosis of diseases. There are a plethora of studies in which 3-NT has been utilized from the pharmacological perspective. However, there is a lack of studies in which the absolute concentration of 3-NT has been reported. Recent breakthrough technologies and modified analytical techniques have been reported to improve the selectivity and sensitivity of 3-NT detection. In this review, we have summarized the modifications to current analytical strategies and advancements in different approaches for 3-NT analysis. For the first time, pre-fabricated biosensors available for 3-NT have been reviewed in this article. A complete discussion on other advanced approaches such as capillary electrophoresis, electron paramagnetic resonance spectroscopy, and electron-vibration-vibration two-dimensional infrared spectroscopy for 3-NT analysis has been made. We have summarized the widest array of conventional and modern analytical techniques reported till date including the recent advancement in the field for the quantification of 3-NT in various types of biological samples.

Acknowledgments

The authors want to thank NIPER-Ahmedabad for providing the required facilities for compiling this review. Authors are also thankful to the Department of Pharmaceuticals, Ministry of Chemical and Fertilizer, New Delhi, India for providing financial support.

Disclosure statement

No potential conflict of interest was reported by the authors.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 451.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.