https://orcid.org/0000-0003-1360-3110![Sample our Physical Sciences journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/110819/TOC-Subject-Sample-2021-Physical-Sciences.jpg"})
Abstract
An overview on the increasing role of capillary electrophoresis in characterization and direct analysis of nanomaterials is herein presented. The niche of electrophoretic approaches in nanometrology is so relevant that nonmetallic, metal, metal oxide nanoparticles, and quantum dots have been analyzed to be targeted via capillary electrophoresis with conventional detection systems or coupling arrangements aimed at increasing selectivity and sensitivity toward either pristine or conjugated nanoparticles. Moreover, parameters altering intrinsic properties of nanoparticles may be optimized to gather the desired results and identify nanomaterials according to their size, shape, or associations with binding agents. The usefulness and quickness of capillary electrophoresis for quantifying or screening ultrasmall-sized particles enables this technique to set an example for analysis of standards or previously synthesized nanostructures in research or routine laboratories. Abundant evidence of the suitability of electrophoretic approaches for characterization and direct determination of nanomaterials in actual samples has been provided in this review, together with a discussion about hyphenation with state-of-the art detectors and comparison between capillary electrophoresis with other separation approaches. This permits scientific community to be optimistic in the short term.
Acknowledgements
The authors wish to thank the Ministerio de Ciencia e Innovación (Spain) and Junta de Comunidades de Castilla-La Mancha for the financial support through projects PID2019-104381GB-I00 and SBPLY/17/180501/000262, respectively.