Recent Advances in Construction and Application of Metal-Nanozymes in Pharmaceutical Analysis

Abstract

Nanozymes, made of emerging nanomaterials, have similar activity to natural enzyme and exhibit promising applications in in the fields of environment, biology and medicine, and food safety science. In recent years, with the deep finding and research to nanozymes by researchers, its application in field of pharmaceutical analysis has emerged gradually, possessing great significance in drug safety evaluation and quality control. This review summarizes the construction of metal nanozymes, strategies to improve their performance and their application in pharmaceutical detection and analysis, especially in detection of target analytes consisting of small molecule medicine macromolecule, toxic and others, which proposes theoretical foundation for development of nanozymes in this field. At the same time, it also provides opportunities and challenges for the construction and application of new nanozymes.

Keywords:

• Application
• detection
• metal nanozymes
• pharmaceutical analysis

Acknowledgments

This work was financially supported by the National Natural Science Foundation of China through the Grant [No. 81950410634]; the Bureau of the International Cooperation of the NSFC and the Foreign Experts Department of the Ministry of Science and Technology of the People’s Republic of China through a Grant for Foreign Youth Project [No. QNJ20200010003]; the National Innovation and Entrepreneurship Training Program for Undergraduate [No. 202110316029Z]; the Innovation and Entrepreneurship Training Program for Undergraduate [No. 202210316316]; China Pharmaceutical University 2019 high-level talent introduction research start-up fund [No. 3150050051].

Disclosure statement

The authors declare that they have no competing interests.