Mouse Models of Food Allergy: How Well do They Simulate the Human Disorder?

Abstract

Food allergy is a growing health problem with serious concerns due to high potential for fatality. Rapid advances in the knowledge on causes and mechanisms as well as in developing effective prevention/therapeutic strategies are needed. To meet these goals, mouse models that simulate the human disorder are highly desirable. During the past decade, several mouse models of food allergies have been reported. Here, we briefly reviewed the human disorder and then critically evaluated these models seeking answers to the following important questions: To what extent do they simulate the human disorder? What are the strengths and limitations of these models? What are the challenges facing this scientific area? Our analysis suggest that: (i) the mouse models, with inherent strengths and limitations, are available for many major food allergies; there is scope for additional model development and validation; (ii) models mostly simulate the severe forms of human disorder with similar immune and clinical features; (iii) the approaches used to develop some of the mouse models may be questionable; and (iv) the specific mechanisms of sensitization as wells as oral elicitation of fatal reactions in both humans and mice remains incompletely understood and therefore warrants further research.

Keywords:

• Food allergy
• mouse model
• systemic anaphylaxis
• allergen
• hypersensitivity

FUNDING

This work was supported by funding from US EPA STAR grants: RD833133; RD834822; Ag Bio-Research, Michigan State University; E.J. Kim is supported by a scholarship (or grant) from the Brain Korea 21 Program, the Ministry of Education, Science, and Technology, Korea.