Mouse Models of Food Allergy: How Well do They Simulate the Human Disorder?

REFERENCES

• Aalberse, R.C., Akkerdaas, J. and van Ree, R. (2001). Cross-reactivity of IgE antibodies to allergens. Allergy. 56(6):478–490.
   PubMed Web of Science ®Google Scholar
• Abonia, J.P. and Rothenberg, M.E. (2011). Eosinophilic esophagitis: rapidly advancing insights. Annu Rev Med. Jan 26. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Aldemir, H., Bars, R. and Herouet-Guicheney, C. (2009). Murine models for evaluating the allergenicity of novel proteins and foods. Regul. Toxicol. Pharmacol. 54(3 Suppl):S52–S57.
   Google Scholar
• Amoli, M.M., Hand, S., Hajeer, A.H., Jones, K.P., Rolf, S., Sting, C., Davies, B.H. and Ollier, W.E. (2002). Polymorphism in the STAT6 gene encodes risk for nut allergy. Genes Immun. 3(4):220–224.
   PubMed Web of Science ®Google Scholar
• Beyer, K., Morrow, E., Li, X.M., Bardina, L., Bannon, G.A., Burks, A.W. and Sampson, H.A. (2001). Effects of cooking methods on peanut allergenicity. J. Allergy Clin. Immunol. 107(6):1077–1081.
   PubMed Web of Science ®Google Scholar
• Birmingham, N.P., Parvataneni, S., Hassan, H.M., Harkema, J., Samineni, S., Navuluri, L., Kelly, C.J. and Gangur, V. (2007). An adjuvant-free mouse model of tree nut allergy using hazelnut as a model tree nut. Int. Arch. Allergy Immunol. 144(3):203–210.
   PubMed Web of Science ®Google Scholar
• Birmingham, N., Gangur, V., Samineni, S., Navuluri, L. and Kelly, C. (2005). Hazelnut Allergy: evidence that hazelnut can directly elicit specific IgE antibody response via activating type 2 cytokines in mice. Int. Arch Allergy Immunol. 137(4):295–302.
   PubMed Web of Science ®Google Scholar
• Birmingham, N., Payankaulam, S., Thanesvorakul, S., Stefura, B., HayGlass, K. and Gangur, V. (2003). An ELISA-based method for measurement of food-specific IgE antibody in mouse serum: an alternative to the passive cutaneous anaphylaxis assay. J. Immunol. Methods. 275(1–2):89–98.
   PubMed Web of Science ®Google Scholar
• Birmingham, N., Thanesvorakul, S. and Gangur, V. (2002). Relative immunogenicity of commonly allergenic foods versus rarely allergenic and nonallergenic foods in mice. J. Food Prot. 65(12):1988–1991.
   PubMed Web of Science ®Google Scholar
• Bjorksten, B. (2005). Genetic and environmental risk factors for the development of food allergy. Curr. Opin. Allergy Clin. Immunol. 5(3):249–253.
   PubMed Web of Science ®Google Scholar
• Bousquet, J., Bjorksten, B., Bruijnzeel-Koomen, C.A., Huggett, A., Ortolani, C., Warner, J.O. and Smith, M. (1998). Scientific criteria and the selection of allergenic foods for product labelling. Allergy. 53(47 Suppl):3–21.
   PubMedGoogle Scholar
• Bowman, C.C. and Selgrade, M.K. (2008a). Differences in allergenic potential of food extracts following oral exposure in mice reflect differences in digestibility: potential approaches to safety assessment. Toxicol. Sci. 102(1):100–109.
   PubMed Web of Science ®Google Scholar
• Bowman, C.C. and Selgrade, M.K. (2008b). Failure to induce oral tolerance in mice is predictive of dietary allergenic potency among foods with sensitizing capacity. Toxicol. Sci. 106(2):435–443.
   PubMed Web of Science ®Google Scholar
• Bowman, C.C. and Selgrade, M.K. (2009). Utility of rodent models for evaluating protein allergenicity. Regul. Toxicol. Pharmacol. 54(3 Suppl):S58–61.
   Google Scholar
• Boyano-Martinez, T., Garcia-Ara, C., Diaz-Pena, J.M. and Martin-Esteban, M. (2002). Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. J. Allergy Clin. Immunol. 110(2):304–309.
   PubMed Web of Science ®Google Scholar
• Boyce, J.A., Assa’ad, A., Burks, A.W., Jones, S.M., Sampson, H.A., Wood, R.A., Plaut, M., Cooper, S.F. and Fenton, M.J. (2011). Guidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-sponsored expert panel report. J. Am. Diet. Assoc. 111(1):17–27.
   PubMed Web of Science ®Google Scholar
• Brannan, J.D. and Turton, J.A. (2011). The inflammatory basis of exercise-induced bronchoconstriction. Phys. Sportsmed. 38(4):67–73.
   Google Scholar
• Branum, A.M. and Lukacs, S.L. (2009). Food allergy among children in the United States. Pediatrics. 124(6):1549–1555.
   PubMed Web of Science ®Google Scholar
• Buchanan, B.B. and Frick, O.L. (2002). The dog as a model for food allergy. Ann. N Y Acad. Sci. 964:173–183.
   PubMed Web of Science ®Google Scholar
• Bush, R.K. and Hefle, S.L. (1996). Food allergens. Crit. Rev. Food Sci. Nutr. 36(Suppl):S119–S163.
   PubMedGoogle Scholar
• Callard, R.E. and Harper, J.I. (2007). The skin barrier, atopic dermatitis and allergy: a role for Langerhans cells? Trends Immunol. 28(7):294–298.
   PubMed Web of Science ®Google Scholar
• Capobianco, F., Butteroni, C., Barletta, B., Corinti, S., Afferni, C., Tinghino, R., Boirivant, M. and Di Felice, G. (2008). Oral sensitization with shrimp tropomyosin induces in mice allergen-specific IgE, T cell response and systemic anaphylactic reactions. Int. Immunol. 20(8):1077–1086.
   PubMed Web of Science ®Google Scholar
• CFIA. (2011). http://active.inspection.gc.ca/eng/util/aze.asp?sid=39.
   Google Scholar
• Chehade, M. and Mayer, L. (2005). Oral tolerance and its relation to food hypersensitivities. J. Allergy Clin. Immunol. 115(1):3–12; quiz 13.
   PubMed Web of Science ®Google Scholar
• Chen, X.W., Lau, K.W., Yang, F., Sun, S,S. and Fung, M.C. (2011). An adjuvant free mouse model of oral allergenic sensitization to rice seeds protein. BMC Gastroenterol. 11:62.
   PubMed Web of Science ®Google Scholar
• Cochrane, S., Beyer, K., Clausen, M., Wjst, M., Hiller, R., Nicoletti, C., Szepfalusi, Z., Savelkoul, H., Breiteneder, H., Manios, Y., Crittenden, R. and Burney, P. (2009). Factors influencing the incidence and prevalence of food allergy. Allergy. 64(9):1246–1255.
   PubMed Web of Science ®Google Scholar
• Cohen, B.L., Noone, S., Munoz-Furlong, A. and Sicherer, S.H. (2004). Development of a questionnaire to measure quality of life in families with a child with food allergy. J. Allergy Clin. Immunol. 114(5):1159–1163.
   PubMed Web of Science ®Google Scholar
• Crittenden, R.G. and Bennett, L.E. (2005). Cow's milk allergy: a complex disorder. J. Am. Coll. Nutr. 24(6 Suppl):582S–591S.
   Google Scholar
• Dahl, D. (2006). Restaurant Industry May Face a Spate of Food Allergy Suits. Lawyers, USA.
   Google Scholar
• De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J.B., Massart, S., Collini, S., Pieraccini, G. and Lionetti, P. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc. Natl. Acad. Sci. U S A. 107(33):14691–14696.
   PubMed Web of Science ®Google Scholar
• Dearman, R.J. and Kimber, I. (2005). Characterisation of immune responses to food allergens in mice. Proc. Nutr. Soc. 64(4):426–433.
   PubMed Web of Science ®Google Scholar
• Dearman, R.J. and Kimber, I. (2007). A mouse model for food allergy using intraperitoneal sensitization. Methods. 41(1):91–98.
   PubMed Web of Science ®Google Scholar
• Dearman, R.J. and Kimber, I. (2009). Animal models of protein allergenicity: potential benefits, pitfalls and challenges. Clin. Exp. Allergy. 39(4):458–468.
   PubMed Web of Science ®Google Scholar
• Dearman, R.J., Caddick, H., Stone, S., Basketter, D.A. and Kimber, I. (2001). Characterization of antibody responses induced in rodents by exposure to food proteins: influence of route of exposure. Toxicology. 167(3):217–231.
   PubMed Web of Science ®Google Scholar
• Dearman, R.J., Caddick, H., Stone, S., Kenna, J.G., Basketter, D.A. and Kimber, I. (2002). Immunogenic properties of rapidly digested food proteins following gavage exposure of mice: a comparison of ovalbumin with a potato acid phosphatase preparation. Food Chem. Toxicol. 40(5):625–633.
   PubMed Web of Science ®Google Scholar
• Dearman, R.J., Skinner, R.A., Herouet, C., Labay, K., Debruyne, E. and Kimber, I. (2003a). Induction of IgE antibody responses by protein allergens: inter-laboratory comparisons. Food Chem. Toxicol. 41(11):1509–1516.
   PubMed Web of Science ®Google Scholar
• Dearman, R.J., Stone, S., Caddick, H.T., Basketter, D.A. and Kimber, I. (2003b). Evaluation of protein allergenic potential in mice: dose-response analyses. Clin. Exp. Allergy. 33(11):1586–1594.
   PubMed Web of Science ®Google Scholar
• Decker, W.W., Campbell, R.L., Manivannan, V., Luke, A., St Sauver, J.L., Weaver, A., Bellolio, M.F., Bergstralh, E.J., Stead, L.G. and Li, J.T. (2008). The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J. Allergy Clin. Immunol. 122(6):1161–1165.
   PubMed Web of Science ®Google Scholar
• Donovan, G.R., Manolios, N., Weiner, J.M., Grennan, D., Huang, Q., Dunckley, H. and Baldo, B.A. (1996). A family study of allergy: segregation with HLA but not with T-cell receptor genes. J. Allergy Clin. Immunol. 97(2):712–713.
   PubMed Web of Science ®Google Scholar
• Dreskin, S.C. (2006). Do HLA genes play a role in the genetics of peanut allergy? Ann. Allergy Asthma Immunol. 96(6):766–768.
   PubMed Web of Science ®Google Scholar
• Droste, J., Vermeire, P., Van Sprundel, M., Bulat, P., Braeckman, L., Myny, K. and Vanhoorne, M. (2005). Occupational exposure among bakery workers: impact on the occurrence of work-related symptoms as compared with allergic characteristics. J. Occup. Environ. Med. 47(5):458–465.
   PubMed Web of Science ®Google Scholar
• Du Toit, G., Katz, Y., Sasieni, P., Mesher, D., Maleki, S.J., Fisher, H.R., Fox, A.T., Turcanu, V., Amir, T., Zadik-Mnuhin, G., Cohen, A., Livne, I. and Lack, G. (2008). Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J. Allergy Clin. Immunol. 122(5):984–991.
   PubMed Web of Science ®Google Scholar
• DunnGalvin, A., Hourihane, J.O., Frewer, L., Knibb, R.C., Oude Elberink, J.N. and Klinge, I. (2006). Incorporating a gender dimension in food allergy research: a review. Allergy. 61(11):1336–1343.
   PubMed Web of Science ®Google Scholar
• EFSA. (2004). http://www.efsa.europa.eu/en/science/nda/nda_opinions/food_allergy/341.html
   Google Scholar
• EPA, U.S (2008). http://www.epa.gov/oppbppd1/biopesticides/pips/starlink_corn.htm.
   Google Scholar
• Finkelman, F.D.(2007). Anaphylaxis: lessons from mouse models. J. Allergy Clin. Immunol. 120(3):506–515; quiz 516-507.
   PubMed Web of Science ®Google Scholar
• Fischer, R., McGhee, J.R., Vu, H.L., Atkinson, T.P., Jackson, R.J. ,Tome, D. and Boyaka, P.N. (2005). Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy. Am. J. Pathol. 167(6):1621–1630.
   PubMed Web of Science ®Google Scholar
• Fleischer, D.M., Conover-Walker, M.K., Matsui, E.C. and Wood, R.A. (2005). The natural history of tree nut allergy. J. Allergy Clin. Immunol. 116(5):1087–1093.
   PubMed Web of Science ®Google Scholar
• Fox, M., Voordouw, J., Mugford, M., Cornelisse, J., Antonides, G. and Frewer, L. (2009). Social and economic costs of food allergies in Europe: Development of a questionnaire to measure costs and health utility. Health Serv. Res. 44(5 Pt 1):1662–1678.
   PubMed Web of Science ®Google Scholar
• Frick, O.L., Teuber, S.S., Buchanan, B.B., Morigasaki, S. and Umetsu, D.T. (2005). Allergen immunotherapy with heat-killed Listeria monocytogenes alleviates peanut and food-induced anaphylaxis in dogs. Allergy. 60(2):243–250.
   PubMed Web of Science ®Google Scholar
• Ganeshan, K., Neilsen, C.V., Hadsaitong, A., Schleimer, R.P., Luo, X. and Bryce, P.J. (2009). Impairing oral tolerance promotes allergy and anaphylaxis: a new murine food allergy model. J. Allergy Clin. Immunol. 123(1):231–238 e234.
   PubMed Web of Science ®Google Scholar
• Garside, P. and Mowat, A.M. (2001). Oral tolerance. Semin Immunol. 13(3):177–185.
   PubMed Web of Science ®Google Scholar
• Gonipeta, B., Parvataneni, S., Paruchuri, P. and Gangur, V. (2010). Long-term characteristics of hazelnut allergy in an adjuvant-free mouse model. Int. Arch Allergy Immunol. 152(3):219–225.
   PubMed Web of Science ®Google Scholar
• Gonipeta, B., Parvataneni, S. ,Tempelman, R.J. and Gangur, V. (2009). An adjuvant-free mouse model to evaluate the allergenicity of milk whey protein. J. Dairy Sci. 92(10):4738–4744.
   PubMed Web of Science ®Google Scholar
• Greer, F.R., Sicherer, S.H. and Burks, A.W. (2008). Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics. 121(1):183–191.
   PubMed Web of Science ®Google Scholar
• Grob, M., Reindl, J., Vieths, S., Wuthrich, B. and Ballmer-Weber, B.K. (2002). Heterogeneity of banana allergy: characterization of allergens in banana-allergic patients. Ann. Allergy Asthma Immunol. 89(5):513–516.
   PubMed Web of Science ®Google Scholar
• Gupta, R.S., Springston, E.E., Warrier, M.R., Smith, B., Kumar, R., Pongracic, J. and Holl, J.L. (2011). The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 128(1):e9–e17.
   PubMed Web of Science ®Google Scholar
• Hadley, C. (2006). Food allergies on the rise? Determining the prevalence of food allergies, and how quickly it is increasing, is the first step in tackling the problem. EMBO Rep. 7(11):1080–1083.
   PubMed Web of Science ®Google Scholar
• Hansen, K.S., Ballmer-Weber, B.K., Luttkopf, D., Skov, P.S., Wuthrich, B., Bindslev-Jensen, C., Vieths, S. and Poulsen, L.K. (2003). Roasted hazelnuts–allergenic activity evaluated by double-blind, placebo-controlled food challenge. Allergy. 58(2):132–138.
   PubMed Web of Science ®Google Scholar
• Hefle, S.L., Nordlee, J.A. and Taylor, S.L. (1996). Allergenic foods. Crit. Rev. Food Sci. Nutr. 36(Suppl):S69–89.
   PubMedGoogle Scholar
• Helm, R.M., Ermel, R.W. and Frick, O.L. (2003). Nonmurine animal models of food allergy. Environ. Health Perspect. 111(2):239–244.
   PubMed Web of Science ®Google Scholar
• Hensel, P. (2011). Nutrition and skin diseases in veterinary medicine. Clin. Dermatol. 28(6):686–693.
   Web of Science ®Google Scholar
• Hommel, K.A., Franciosi, J.P., Hente, E.A., Ahrens, A. and Rothenberg, M.E. (2011). Treatment Adherence in Pediatric Eosinophilic Gastrointestinal Disorders. J Pediatr Psychol. Nov 10. [Epub ahead of print]
   Web of Science ®Google Scholar
• Hourihane, J.O., Kilburn, S.A., Dean, P. and Warner, J.O. (1997). Clinical characteristics of peanut allergy. Clin. Exp. Allergy. 27(6):634–639.
   PubMed Web of Science ®Google Scholar
• Hourihane, J.O., Smith, P.K. and Strobel, S. (2002). Food allergy in children. Indian J. Pediatr. 69(1):61–67.
   PubMedGoogle Scholar
• Hudson, T.J. (2006). Skin barrier function and allergic risk. Nat. Genet. 38(4):399–400.
   PubMed Web of Science ®Google Scholar
• Jonsson, F., Mancardi, D.A., Kita, Y., Karasuyama, H., Iannascoli, B., Van Rooijen, N., Shimizu, T., Daeron, M. and Bruhns, P. (2011). Mouse and human neutrophils induce anaphylaxis. J. Clin. Invest. 121(4):1484–1496.
   PubMed Web of Science ®Google Scholar
• Kagan, R.S. (2003). Food allergy: an overview. Environ Health Perspect. 111(2):223–225.
   PubMed Web of Science ®Google Scholar
• Keet, C.A., Matsui, E.C., Dhillon, G., Lenehan, P., Paterakis, M. and Wood, R.A. (2009). The natural history of wheat allergy. Ann. Allergy Asthma Immunol. 102(5):410–415.
   PubMed Web of Science ®Google Scholar
• Kelly, C. and Gangur, V. (2009). Sex Disparity in Food Allergy: Evidence from the PubMed Database. J. Allergy (Cairo) 2009:159845.
   PubMedGoogle Scholar
• Khodoun, M.V., Strait, R., Armstrong, L., Yanase, N. and Finkelman, F.D. (2011). Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis. Proc. Natl. Acad. Sci. U S A. 108(30):12413–12418.
   PubMed Web of Science ®Google Scholar
• Kimber, I. and Dearman, R.J. (2002). Approaches to assessment of the allergenic potential of novel proteins in food from genetically modified crops. Toxicol. Sci. 68(1):4–8.
   PubMed Web of Science ®Google Scholar
• Kimber, I., Betts, C.J. and Dearman, R.J. (2003a). Assessment of the allergenic potential of proteins. Toxicol. Lett. 140–141:297–302.
   PubMed Web of Science ®Google Scholar
• Kimber, I., Dearman, R.J., Penninks, A.H., Knippels, L.M., Buchanan, R.B., Hammerberg, B., Jackson, H.A. and Helm, R.M. (2003b). Assessment of protein allergenicity on the basis of immune reactivity: animal models. Environ. Health Perspect. 111(8):1125–1130.
   PubMed Web of Science ®Google Scholar
• Kimber, I., Lumley, C.E. and Metcalfe, D.D. (1997). Allergenicity of proteins. Hum. Exp. Toxicol. 16(9):516–518.
   PubMed Web of Science ®Google Scholar
• Kimber, I., Stone, S. and Dearman, R.J. (2003c). Assessment of the inherent allergenic potential of proteins in mice. Environ. Health Perspect. 111(2):227–231.
   PubMed Web of Science ®Google Scholar
• Knippels, L.M. and Penninks, A.H. (2003). Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model. Environ. Health Perspect. 111(2):233–238.
   PubMed Web of Science ®Google Scholar
• Knippels, L.M., Penninks, A.H. and Houben, G.F. (1998a). Continued expression of anti-soy protein antibodies in rats bred on a soy protein-free diet for one generation: the importance of dietary control in oral sensitization research. J. Allergy Clin. Immunol. 101(6 Pt 1):815–820.
   PubMed Web of Science ®Google Scholar
• Knippels, L.M., Penninks, A.H., Spanhaak, S. and Houben, G.F. (1998b). Oral sensitization to food proteins: a Brown Norway rat model. Clin. Exp. Allergy. 28(3):368–375.
   PubMed Web of Science ®Google Scholar
• Kroghsbo, S., Christensen, H.R. and Frokiaer, H. (2003). Experimental parameters differentially affect the humoral response of the cholera-toxin-based murine model of food allergy. Int. Arch Allergy Immunol. 131(4):256–263.
   PubMed Web of Science ®Google Scholar
• Lack, G. and Penagos, M. (2011). Early feeding practices and development of food allergies. Nestle Nutr. Workshop Ser. Pediatr. Program. 68:169–186.
   PubMedGoogle Scholar
• Lack, G., Fox, D., Northstone, K. and Golding, J. (2003). Factors associated with the development of peanut allergy in childhood. N. Engl. J. Med. 348(11):977–985.
   PubMed Web of Science ®Google Scholar
• Ladics, G.S. (2008). Current codex guidelines for assessment of potential protein allergenicity. Food Chem. Toxicol. 46(Suppl 10):S20–S23.
   PubMed Web of Science ®Google Scholar
• Ladics, G.S. and Selgrade, M.K. (2009). Identifying food proteins with allergenic potential: evolution of approaches to safety assessment and research to provide additional tools. Regul. Toxicol. Pharmacol. 54(3 Suppl):S2–6.
   PubMed Web of Science ®Google Scholar
• Ladics, G.S., Holsapple, M.P., Astwood, J.D., Kimber, I., Knippels, L.M., Helm, R.M. and Dong, W. (2003). Workshop overview: approaches to the assessment of the allergenic potential of food from genetically modified crops. Toxicol. Sci. 73(1):8–16.
   PubMed Web of Science ®Google Scholar
• Ladics, G.S., Knippels, L.M., Penninks, A.H., Bannon, G.A., Goodman, R.E. and Herouet-Guicheney, C. (2010). Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops. Regul. Toxicol. Pharmacol. 56(2):212–224.
   PubMed Web of Science ®Google Scholar
• Lehrer, S.B., Ayuso, R. and Reese, G. (2002). Current understanding of food allergens. Ann. NY Acad. Sci. 964:69–85.
   PubMed Web of Science ®Google Scholar
• Leung, P.S., Lee, Y.S., Tang, C.Y., Kung, W.Y., Chuang, Y.H., Chiang, B.L., Fung, M.C. and Chu, K.H. (2008). Induction of shrimp tropomyosin-specific hypersensitivity in mice. Int. Arch Allergy Immunol. 147(4):305–314.
   PubMed Web of Science ®Google Scholar
• Li, X.M., Kleiner, G., Huang, C.K., Lee, S.Y., Schofield, B., Soter, N.A. and Sampson, H.A. (2001). Murine model of atopic dermatitis associated with food hypersensitivity. J. Allergy Clin. Immunol. 107(4):693–702.
   PubMed Web of Science ®Google Scholar
• Li, X.M., Schofield, B.H., Huang, C.K., Kleiner, G.I. and Sampson, H.A. (1999b). A murine model of IgE-mediated cow's milk hypersensitivity. J. Allergy Clin. Immunol. 103(2 Pt 1):206–214.
   PubMed Web of Science ®Google Scholar
• Li, X.M., Serebrisky, D., Lee, S.Y., Huang, C.K., Bardina, L., Schofield, B.H., Stanley, J.S., Burks, A.W., Bannon, G.A. and Sampson, H.A. (2000). A murine model of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J. Allergy Clin. Immunol. 106(1 Pt 1):150–158.
   PubMed Web of Science ®Google Scholar
• Li, X., Huang, C.K., Schofield, B.H., Burks, A.W., Bannon, G.A., Kim, K.H., Huang, S.K. and Sampson, H.A. (1999a). Strain-dependent induction of allergic sensitization caused by peanut allergen DNA immunization in mice. J. Immunol. 162(5):3045–3052.
   PubMed Web of Science ®Google Scholar
• Liu, X., Feng, J., Xu, Z.R., Wang, Y.Z. and Liu, J.X. (2008). Oral allergy syndrome and anaphylactic reactions in BALB/c mice caused by soybean glycinin and beta-conglycinin. Clin. Exp. Allergy. 38(2):350–356.
   PubMed Web of Science ®Google Scholar
• Lowell, C.A. (2011). Neutrophils give us a shock. J. Clin. Invest. 121(4):1260–1263.
   PubMed Web of Science ®Google Scholar
• Melgert, B.N., Postma, D.S., Kuipers, I., Geerlings, M., Luinge, M.A., van der Strate, B.W., Kerstjens, H.A., Timens, W. and Hylkema, M.N. (2005). Female mice are more susceptible to the development of allergic airway inflammation than male mice. Clin. Exp. Allergy. 35(11):1496–1503.
   PubMed Web of Science ®Google Scholar
• Metcalfe, D.D., AStwood, J.D., Townsend, R., Sampson, H.A., Taylor, S.L. and Fuchs, R.L. (1996). Assessment of the allergenic potential of foods derived from genetically engineered crop plants. Crit. Rev. Food Sci. Nutr. 36(Suppl):S165–186.
   PubMed Web of Science ®Google Scholar
• Metcalfe, D.D. (2003). Introduction: what are the issues in addressing the allergenic potential of genetically modified foods? Environ. Health Perspect. 111(8):1110–1113.
   PubMed Web of Science ®Google Scholar
• Mondoulet, L., Dioszeghy, V., Vanoirbeek, J.A., Nemery, B., Dupont, C. and Benhamou, P.H. (2011). Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts. Int. Arch Allergy Immunol. 154(4):299–309.
   PubMed Web of Science ®Google Scholar
• Morafo, V., Srivastava, K., Huang, C.K., Kleiner, G., Lee, S.Y., Sampson, H.A. and Li, A.M. (2003). Genetic susceptibility to food allergy is linked to differential TH2-TH1 responses in C3H/HeJ and BALB/c mice. J. Allergy Clin. Immunol. 111(5):1122–1128.
   PubMed Web of Science ®Google Scholar
• Morisset, M., Moneret-Vautrin, D.A., Kanny, G., Guenard, L., Beaudouin, E., Flabbee, J. and Hatahet, R. (2003). Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo-controlled oral challenges. Clin. Exp. Allergy. 33(8):1046–1051.
   PubMed Web of Science ®Google Scholar
• Morita, E., Kunie, K. and Matsuo, H. (2007). Food-dependent exercise-induced anaphylaxis. J. Dermatol. Sci. 47(2):109–117.
   PubMed Web of Science ®Google Scholar
• Murphy, K., Travers, P. and Walport, M. (2008). The Adaptive Immune Response: The Humoral Immune Response. in Janeway's Immuno Biology. 7 ed. Garland Publishing.
   Google Scholar
• Navuluri, L., Parvataneni, S., Hassan, H., Birmingham, N.P., Kelly, C. and Gangur, V. (2006). Allergic and anaphylactic response to sesame seeds in mice: identification of Ses i 3 and basic subunit of 11s globulins as allergens. Int. Arch Allergy Immunol. 140(3):270–276.
   PubMed Web of Science ®Google Scholar
• Nowak-Wegrzyn, A. and Sampson, H.A. (2011). Future therapies for food allergies. J. Allergy Clin. Immunol. 127(3):558–573; quiz 574-555.
   PubMed Web of Science ®Google Scholar
• Ortolani, C., Ballmer-Weber, B.K., Hansen, K.S., Ispano, M., Wuthrich, B., Bindslev-Jensen, C., Ansaloni, R., Vannucci, L., Pravettoni, V., Scibilia, J., Poulsen, L.K. and Pastorello, E.A. (2000). Hazelnut allergy: a double-blind, placebo-controlled food challenge multicenter study. J. Allergy Clin. Immunol. 105(3):577–581.
   PubMed Web of Science ®Google Scholar
• Parvataneni, S., Birmingham, N.P., Gonipeta, B. and Gangur, V. (2009a). Dominant, non-MHC genetic control of food allergy in an adjuvant-free mouse model. Int. J. Immunogenet. 36(5):261–267.
   PubMed Web of Science ®Google Scholar
• Parvataneni, S., Gonipeta, B., Tempelman, R.J. and Gangur, V. (2009b). Development of an Adjuvant-Free Cashew Nut Allergy Mouse Model. Int. Arch Allergy Immunol. 149(4):299–304.
   PubMed Web of Science ®Google Scholar
• Patel, D.A., Holdford, D.A., Edwards, E. and Carroll, N.V. (2011). Estimating the economic burden of food-induced allergic reactions and anaphylaxis in the United States. J. Allergy Clin. Immunol. 128(1):110–115 e115.
   PubMed Web of Science ®Google Scholar
• Plenge, R.M. (2010). Unlocking the pathogenesis of celiac disease. Nat Genet. 42(4):281–282.
   PubMed Web of Science ®Google Scholar
• Proust, B., Astier, C., Jacquenet, S., Ogier, V., Magueur, E., Roitel, O., Belcourt, C., Morisset, M., Moneret-Vautrin, D.A., Bihain, B.E. and Kanny, G. (2008). A single oral sensitization to peanut without adjuvant leads to anaphylaxis in mice. Int. Arch Allergy Immunol. 146(3):212–218.
   PubMed Web of Science ®Google Scholar
• Rajan, T.V. (2003). The Gell-Coombs classification of hypersensitivity reactions: A re-interpretation. Trends Immunol. 24(7):376–379.
   PubMed Web of Science ®Google Scholar
• Rook, G.A. (2011). Hygiene and other early childhood influences on the subsequent function of the immune system. Dig. Dis. 29(2):144–153.
   PubMed Web of Science ®Google Scholar
• Sampson, H.A. (2001). Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J. Allergy Clin. Immunol. 107(5):891–896.
   PubMed Web of Science ®Google Scholar
• Sampson, H.A. (2003). Food allergy. J. Allergy Clin. Immunol. 111(2 Suppl):S540–547.
   Google Scholar
• Sampson, H.A. (2004). Update on food allergy. J. Allergy Clin. Immunol. 113(5):805–819; quiz 820.
   PubMed Web of Science ®Google Scholar
• Sampson, H.A. and Burks, A.W. (1996). Mechanisms of food allergy. Annu. Rev. Nutr. 16:161–177.
   PubMed Web of Science ®Google Scholar
• Sampson, H.A. and Ho, D.G. (1997). Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J. Allergy Clin. Immunol. 100(4):444–451.
   PubMed Web of Science ®Google Scholar
• Sathe, S.K. and Sharma, G.M. (2009). Effects of food processing on food allergens. Mol. Nutr. Food Res. 53(8):970–978.
   PubMed Web of Science ®Google Scholar
• Saxon, A. and Diaz-Sanchez, D. (2005). Air pollution and allergy: you are what you breathe. Nat. Immunol. 6(3):223–226.
   PubMed Web of Science ®Google Scholar
• Selgrade, M.K., Bowman, C.C., Ladics, G.S., Privalle, L. and Laessig, S.A. (2009). Safety assessment of biotechnology products for potential risk of food allergy: implications of new research. Toxicol. Sci. 110(1):31–39.
   PubMed Web of Science ®Google Scholar
• Selgrade, M.K., Kimber, I., Goldman, L. and Germolec, D.R. (2003). Assessment of allergenic potential of genetically modified foods: an agenda for future research. Environ. Health Perspect. 111(8):1140–1141.
   PubMed Web of Science ®Google Scholar
• Shimamoto, S.R. and Bock, S.A. (2002). Update on the clinical features of food-induced anaphylaxis. Curr. Opin. Allergy Clin. Immunol. 2(3):211–216.
   PubMedGoogle Scholar
• Shreffler, W.G., Charlop-Powers, Z. and Sicherer, S.H. (2006). Lack of association of HLA class II alleles with peanut allergy. Ann. Allergy Asthma Immunol. 96(6):865–869.
   PubMed Web of Science ®Google Scholar
• Sicherer, S.H. (2007). Food for thought on prevention and treatment of atopic disease through diet. J. Pediatr. 151(4):331–333.
   PubMed Web of Science ®Google Scholar
• Sicherer, S.H. (2011). Epidemiology of food allergy. J. Allergy Clin. Immunol. 127(3):594–602.
   PubMed Web of Science ®Google Scholar
• Sicherer, S.H. and Sampson, H.A. (1999). Cow's milk protein-specific IgE concentrations in two age groups of milk-allergic children and in children achieving clinical tolerance. Clin. Exp. Allergy. 29(4):507–512.
   PubMed Web of Science ®Google Scholar
• Sicherer, S.H. and Sampson, H.A. (2006). Food allergy. J. Allergy Clin. Immunol. 117(2 Suppl Mini-Primer):S470–S475.
   PubMed Web of Science ®Google Scholar
• Sicherer, S.H. and Sampson, H.A. (2009). Food allergy: recent advances in pathophysiology and treatment. Annu. Rev. Med. 60:261–277.
   PubMed Web of Science ®Google Scholar
• Sicherer, S.H. and Sampson, H.A. (2010). Food allergy. J. Allergy Clin. Immunol. 125(2 Suppl 2):S116–125.
   PubMed Web of Science ®Google Scholar
• Skolnick, H.S., Conover-Walker, M.K., Koerner, C.B., Sampson, H.A., Burks, A.W. and Wood, R.A. (2001). The natural history of peanut allergy. J. Allergy Clin. Immunol. 107(2):367–374.
   PubMed Web of Science ®Google Scholar
• Snider, D.P., Marshall, J.S., Perdue, M.H. and Liang, H. (1994). Production of IgE antibody and allergic sensitization of intestinal and peripheral tissues after oral immunization with protein Ag and cholera toxin. J. Immunol. 153(2):647–657.
   PubMed Web of Science ®Google Scholar
• Sollid, L.M. (2002). Coeliac disease: dissecting a complex inflammatory disorder. Nat. Rev. Immunol. 2(9):647–655.
   PubMed Web of Science ®Google Scholar
• Soyer, O.U. and Sekerel, B.E. (2008). Food dependent exercise induced anaphylaxis or exercise induced anaphylaxis? Allergol. Immunopathol. (Madr) 36(4):242–243.
   PubMed Web of Science ®Google Scholar
• Strid, J., Hourihane, J., Kimber, I., Callard, R. and Strobel, S. (2005). Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization. Clin. Exp. Allergy. 35(6):757–766.
   PubMed Web of Science ®Google Scholar
• Tan, T.H., Ellis, J.A., Saffery, R. and Allen, K.J. (2012). The role of genetics and environment in the rise of childhood food allergy. Clin. Exp. Allergy. 42(1):20–29.
   PubMed Web of Science ®Google Scholar
• Teuber, S.S. and Beyer, K. 2004. Peanut, tree nut and seed allergies. Curr. Opin. Allergy Clin. Immunol. 4(3):201–203.
   PubMedGoogle Scholar
• USFDA. (2006). http://www.fda.gov/food/labelingnutrition/foodallergens-labeling/guidancecomplianceregulatoryinformation/ucm106108.htm
   Google Scholar
• USFDA. (2011). http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm-254504.shtm
   Google Scholar
• Venugopal, G., Yang, M., Luo, Z., Salo, D., Cheang, M. and Mohapatra, S.S. (1995). Analysis of Tcrvb8, Il4, and Ifg as genetic predisposition factors for atopic IgE response in a murine model. J. Immunol. 155(11):5463–5470.
   PubMed Web of Science ®Google Scholar
• Wang, J. and Sampson, H.A. (2007). Food anaphylaxis. Clin. Exp. Allergy. 37(5):651–660.
   PubMed Web of Science ®Google Scholar
• Wang, J. and Sampson, H.A. (2009). Food allergy: Recent advances in pathophysiology and treatment. Allergy Asthma Immunol. Res. 1(1):19–29.
   PubMed Web of Science ®Google Scholar
• Wang, J. and Sampson, H.A. (2011). Food allergy. J. Clin. Invest. 121(3):827–835.
   PubMed Web of Science ®Google Scholar
• Watura, J.C. (2002). Nut allergy in schoolchildren: a survey of schools in the Severn NHS Trust. Arch Dis. Child. 86(4):240–244.
   PubMed Web of Science ®Google Scholar
• Wensing, M., Penninks, A.H., Hefle, L.S., Akkerdaas, J.H., van Ree, R., Koppelman, S.J., Bruijnzeel-Koomen, C.A. and Knulst, A.C. (2002). The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind, placebo-controlled food challenges. Clin. Exp. Allergy. 32(12):1757–1762.
   PubMed Web of Science ®Google Scholar